The entorhinal cortex and cognitive impairment in schizophrenia: A comprehensive review

被引：0

作者：

Li, Kun ^{[1
,2
]}

Qian, Liju ^{[1
]}

Zhang, Chenchen ^{[1
]}

Zhang, Jiajia ^{[3
]}

Xue, Chuang ^{[4
,5
]}

Zhang, Yuebing ^{[1
]}

Deng, Wei ^{[4
,5
,6
]}

机构：

[1] Shandong Daizhuang Hosp, Jining 272075, Shandong, Peoples R China

[2] Jining Key Lab Neuromodulat, Jining 272075, Shandong, Peoples R China

[3] Xinxiang Med Univ, Dept Psychol, Xinxiang 453003, Henan, Peoples R China

[4] Zhejiang Univ, Sch Med, Affiliated Mental Hlth Ctr, Hangzhou 310063, Zhejiang, Peoples R China

[5] Zhejiang Univ, Hangzhou Peoples Hosp 7, Sch Med, Hangzhou 310063, Zhejiang, Peoples R China

[6] Zhejiang Univ, Liangzhu Lab, MOE Frontier Sci Ctr Brain Sci & Brain Machine Int, State Key Lab Brain Machine Intelligence, 1369 West Wenyi Rd, Hangzhou 311121, Peoples R China

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2025年 / 136卷

关键词：

Schizophrenia; Entorhinal cortex; Cognitive impairment; Olfactory dysfunction; GENE-EXPRESSION; CORTICAL THICKNESS; TEMPORAL-LOBE; OLFACTORY IDENTIFICATION; INDIVIDUALS; MONKEY; ABNORMALITIES; CONNECTIVITY; ASSOCIATIONS; HIPPOCAMPUS;

D O I：

10.1016/j.pnpbp.2024.111218

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Schizophrenia, a severe mental illness characterized by cognitive impairment and olfactory dysfunction, remains an enigma with its pathological mechanism yet to be fully elucidated. The entorhinal cortex, a pivotal structure involved in numerous neural loop circuits related to olfaction, cognition, and emotion, has garnered significant attention due to its structural and functional abnormalities, which have been implicated in the pathogenesis of schizophrenia. This review focuses on the abnormal structural and functional changes in the entorhinal cortex in schizophrenia patients, as evidenced by neuroimaging, cellular biology, and genetic studies. These changes are posited to play a crucial role in the pathogenesis of cognitive impairment in schizophrenia. Furthermore, this review explores the various intervention strategies targeting the entorhinal cortex in current treatment modalities and proposes potential directions for future research endeavors, thereby providing a novel perspective on unraveling the complexity of neural mechanisms underlying schizophrenia and developing innovative therapeutic approaches for schizophrenia.

引用

页数：7

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