Photocatalytic Degradation of Ciprofloxacin: A Combined Experimental and Theoretical Study Using Curcumin and Hydrogen Peroxide

被引:0
作者
de Paiva, Florida L. P. [1 ]
Silva, Maria Vivian C. [1 ]
Mendonca, Ana Lara F. [1 ]
Araujo, Cristiane S. [1 ]
Sallum, Loide O. [2 ]
de Aguiar, Antonio S. N. [1 ]
Lima, Alessandra R. [3 ]
Napolitano, Hamilton B. [1 ,4 ]
Calvete, Mario J. F. [5 ]
Dias, Lucas D. [1 ]
机构
[1] Univ Evangel Goias, Lab Novos Mat, BR-75083515 Anapolis, GO, Brazil
[2] Univ Evangel Goias, Lab Ciencias Farmaceut, BR-75083515 Anapolis, GO, Brazil
[3] Univ Sao Paulo, Lab Biofoton Ambiental, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil
[4] Univ Estadual Goias, Grp Quim Teor & Estrutural Anapolis, BR-75083515 Anapolis, GO, Brazil
[5] Univ Coimbra, Ctr Quim Coimbra, Dept Quim, Rua Larga, P-3004535 Coimbra, Portugal
基金
巴西圣保罗研究基金会;
关键词
photodegradation; environment; antibiotic; ciprofloxacin; curcumin; hydrogen peroxide; molecular modeling; DENSITY; APPROXIMATION; EXCHANGE; STATES; WATER;
D O I
10.3390/separations11090260
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Contamination of soil, water, and wastewater by pharmaceuticals, including antibiotics, is a global health problem. This work evaluated the use of a natural compound, curcumin (CUR), as a homogeneous photocatalyst, together with hydrogen peroxide (H2O2) as a benign oxidant, to promote the photodegradation of ciprofloxacin (CIP). Furthermore, we carried out theoretical calculations using density functional theory (DFT) to assess the chemical reactivity of ciprofloxacin. In addition, the intermolecular interaction patterns of two crystalline polymorphs of the antibiotic drug were analyzed through Hirshfeld surfaces. Finally, calculations using the TD-DFT formalism were carried out to understand the effects on the CIP molecule caused by the simultaneous presence of the CUR molecule and ultraviolet-visible light (UV-Vis). A photooxidative effect was observed in the presence of the CUR photocatalyst (CIP + CUR (1:0.5)), resulting in a degradation of CIP of up to 24.4%. However, increasing the concentration of the CUR photocatalyst (ciprofloxacin + curcumin (1:1)) decreased the photodegradation of CIP, which may be caused by competition between the CIP molecule and CUR for ROS generated in situ. Additionally, the calculation results showed that the electronic excitations caused by the associated CIP + CUR structures affect the CIP molecule, resulting in the effects observed experimentally. The results show that CUR, when applied as a photosensitizing catalyst, presents synergistic potential with H2O2 in the photocatalytic degradation of ciprofloxacin. This photocatalytic process can be applied to the environmental remediation of pharmaceutical micropollutants, a subject of ongoing studies.
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页数:14
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