Landscape of B lymphocytes and plasma cells in digestive tract carcinomas

被引：0

作者：

Dimopoulou, Konstantina ^{[1
]}

Tiniakos, Dina ^{[2
,3
]}

Arkadopoulos, Nikolaos ^{[4
]}

Foukas, Periklis G. ^{[5
]}

机构：

[1] Hippokration Gen Hosp Athens, Dept Gastroenterol, Leof Vasilissis Sofias 114, Athens 11527, Greece

[2] Natl & Kapodistrian Univ Athens, Aretaie Hosp, Med Sch, Dept Pathol, Athens, Greece

[3] Newcastle Univ, Translat & Clin Res Inst, Fac Med Sci, Newcastle Upon Tyne, England

[4] Natl & Kapodistrian Univ Athens, ATTIKON Univ Hosp, Med Sch, Dept Surg 4, Athens, Greece

[5] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Med Sch, Dept Pathol 2, Athens, Greece

来源：

ANNALS OF GASTROENTEROLOGY | 2025年 / 38卷 / 01期

关键词：

B lymphocytes; plasma cells; digestive tract carcinomas; TERTIARY LYMPHOID STRUCTURES; HEPATOCELLULAR-CARCINOMA; IMMUNE CELLS; TUMOR MICROENVIRONMENT; INFLAMMATORY RESPONSE; FAVORABLE PROGNOSIS; PANCREATIC-CANCER; INFILTRATION; ESOPHAGEAL; SURVIVAL;

D O I：

10.20524/aog.2024.0936

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Digestive tract carcinomas are the most commonly occurring cancers worldwide, but their prognosis with traditional treatments remains poor. T lymphocytes are well-recognized as crucial components of effective anti-tumor immunity, and current immunotherapeutic strategies concentrate mainly on T-cell-mediated immunity reinforcement, whereas the role of B lymphocytes and plasma cells (PCs) has been neglected in the past, and it is only recently that these cells have been considered as key players in the tumor microenvironment (TME). In this review, we describe the complex dual role of B lymphocytes and PCs in promoting and inhibiting tumor progression in the TME of digestive tract carcinomas, and we demonstrate their prognostic value. Furthermore, we highlight their controversial function in cancer and nominate them as additional therapeutic targets for the development of new treatment interventions that might alter the dismal prognosis of digestive tract tumors.

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