Role of Hb to RDW ratio in metastatic renal cell carcinoma patients treated with first-line immunotherapy combinations

被引：1

作者：

Coriano, Matilde ^{[1
,2
]}

Lazzarin, Alessandro ^{[1
,2
]}

Maffezzoli, Michele ^{[1
,2
]}

Santoni, Matteo ^{[3
]}

Mazzaschi, Giulia ^{[1
,2
]}

Rodella, Sara ^{[4
]}

Simoni, Nicola ^{[5
]}

Lai, Eleonora ^{[6
]}

Maruzzo, Marco ^{[6
]}

Basso, Umberto ^{[6
]}

Bimbatti, Davide ^{[6
]}

Iacovelli, Roberto ^{[7
]}

Anghelone, Annunziato ^{[7
]}

Fiala, Ondrej ^{[8
,9
,10
]}

Rebuzzi, Sara Elena ^{[11
,12
]}

Fornarini, Giuseppe ^{[13
]}

Lolli, Cristian ^{[14
]}

Massari, Francesco ^{[15
]}

Rosellini, Matteo ^{[15
]}

Mollica, Veronica ^{[15
]}

Nasso, Cecilia ^{[16
]}

Acunzo, Alessandro ^{[1
,2
]}

Silini, Enrico Maria ^{[1
,17
]}

Quaini, Federico ^{[1
]}

De Filippo, Massimo ^{[18
]}

Brunelli, Matteo ^{[19
]}

Banna, Giuseppe L. ^{[20
,21
]}

Rescigno, Pasquale ^{[22
]}

Signori, Alessio ^{[23
]}

Buti, Sebastiano ^{[1
,2
]}

机构：

[1] Univ Parma, Dept Med & Surg, Via Gramsci 14, I-43126 Parma, Italy

[2] Univ Hosp Parma, Med Oncol Unit, Parma, Italy

[3] Macerata Hosp, Oncol Unit, Macerata, Italy

[4] Univ Brescia, Med Oncol Unit, Brescia, Italy

[5] Univ Hosp Parma, Radiotherapy Unit, Parma, Italy

[6] Ist Oncol Veneto IOV IRCCS, Dept Oncol, Oncol Unit, Padua, Italy

[7] Fdn Policlin Univ Agostino Gemelli IRCCS, Med Oncol, Rome, Italy

[8] Charles Univ Prague, Fac Med, Dept Oncol & Radiotherapeut, Plzen, Czech Republic

[9] Charles Univ Prague, Univ Hosp Pilsen, Plzen, Czech Republic

[10] Charles Univ Prague, Fac Med Pilsen, Biomed Ctr, Plzen, Czech Republic

[11] Osped San Paolo Inst, Med Oncol Unit, Savona, Italy

[12] DIBRIS Univ Genova, Dept Internal Med & Med Specialties DiMI, Genoa, Italy

[13] IRCCS Osped Policlin San Martino, Med Oncol Unit 1, Genoa, Italy

[14] IRCCS Ist Romagnolo Studio Tumori IRST Dino Amador, Dept Med Oncol, Meldola, Italy

[15] IRCCS Azienda Osped Univ Bologna, Med Oncol, Bologna, Italy

[16] Osped Santa Corona, Pietra Ligure, Italy

[17] Univ Hosp Parma, Pathol Unit, Parma, Italy

[18] Univ Parma, Parma, Italy

[19] Univ Verona, Verona, Italy

[20] Portsmouth Hosp Univ NHS Trust, Cardiol, Portsmouth, England

[21] Univ Portsmouth, Portsmouth, England

[22] Newcastle Univ, Newcastle Upon Tyne, England

[23] DIBRIS Univ Genova, Genoa, Italy

来源：

IMMUNOTHERAPY | 2025年 / 17卷 / 01期

关键词：

Prognostic score; hemoglobin; ratio; metastatic renal cell carcinoma; immune checkpoint inhibitors; tyrosine-kinase inhibitors; NLR; RDW; DISTRIBUTION WIDTH; SUNITINIB; MACROCYTOSIS; ALPHA;

D O I：

10.1080/1750743X.2025.2452145

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

BackgroundThe present study aimed to investigate the prognostic and predictive roles of Hb/RDW ratio in patients with mRCC treated with first-line immunotherapy combinations (TKI plus ICI or ICI plus ICI).Materials and methodsWe performed a sub-analysis of a multicenter retrospective observational study (ARON-1 project) involving patients with mRCC treated with first-line immunotherapy combinations.ResultsThree hundred and twenty-nine patients were enrolled, 244 males and 85 females. Median age was 65.5 years. The prognostic impact of the Hb/RDW ratio on PFS and OS was observed in the whole population examined. Hb/RDW ratio had a correlation with neutrophil-to-lymphocyte ratio (NLR), a blood inflammatory parameter.ConclusionHb/RDW ratio is a new inflammatory prognostic factor, easy to use in daily clinical practice. Prognostic factors are crucial to improve counseling of patients with metastatic renal cell carcinoma treated with first-line immunotherapy combinations. Our goal is to explore the role of Hemoglobin to RDW ratio in predicting progression-free survival and overall survival.

引用

页码：25 / 35

页数：11

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