Fatal acute liver failure following norovirus gastroenteritis in a child: A case report

被引：0

作者：

Taha, Rabab ^{[1
]}

Elazhary, Noura ^{[2
]}

Alqhtani, Sarah ^{[3
,4
]}

Almansouri, Walaa ^{[4
,5
]}

机构：

[1] Int Med Ctr Hosp, Dept Internal Med, Hail St, Jeddah 23214, Saudi Arabia

[2] Al Murjan Hosp, Dept Pediat Infect Dis, Jeddah, Saudi Arabia

[3] King Saud Bin Abdulaziz Univ Hlth Sci, Coll Med, Jeddah, Saudi Arabia

[4] King Abdullah Int Med Res Ctr, Jeddah, Saudi Arabia

[5] King Saud Bin Abdulaziz Univ Hlth Sci, Pediat Infect Dis, King Abdulaziz Med City, Jeddah, Saudi Arabia

来源：

JOURNAL OF INFECTION AND PUBLIC HEALTH | 2025年 / 18卷 / 04期

关键词：

Acute gastroenteritis; Norovirus; Liver dysfunction; Acute liver failure; Hepatitis; Case report; INFECTION;

D O I：

10.1016/j.jiph.2025.102675

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Norovirus is the leading cause of acute gastroenteritis and rarely present with extra-intestinal manifestations. There are few reported cases of hepatitis following norovirus gastroenteritis, with no documented fatalities. We present a case of fatal acute hepatitis following norovirus gastroenteritis in a child. The patient was a previously healthy 6-year-old boy who presented with diarrhea, vomiting, and fever. He was admitted and treated supportively as a case of acute gastroenteritis. Despite treatment, he rapidly developed acute liver failure in the course of gastroenteritis. Other potential causes including drugs and other possible viral infections were ruled out, only norovirus was isolated from his stool. The patient's liver function continued to deteriorate leading to fulminant liver failure and death within days. (c) 2025 The Author(s). Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页数：3

共 10 条

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