Long-term mortality rates after lower extremity amputation in individuals with and without diabetes mellitus (DUDE-10): A retrospective matched cohort study

被引：0
作者：
Rosien, L. [1 ,2 ,3 ,4 ]
Bilo, H. J. G. [3 ,4 ]
Oskam, J. [5 ]
Ruwaard, D. [6 ]
Gans, R. O. B. [3 ]
Edens, M. A. [7 ]
Molegraaf, M. J. [5 ]
van Dijk, P. R. [1 ,3 ]
机构：
[1] Isala, Diabet Ctr, Dr Stolteweg 2, NL-8025 AB Zwolle, Netherlands
[2] Innofeet, Faradaystr 7, NL-8013 PH Zwolle, Netherlands
[3] Univ Med Ctr Groningen, Dept Internal Med, Hanzepl 1, NL-9713 GZ Groningen, Netherlands
[4] Res Ctr Chron Dis, Dokter Deenweg 1-11, NL-8025 BP Zwolle, Netherlands
[5] Isala, Dept Surg, Dr Stolteweg 2, NL-8025 AB Zwolle, Netherlands
[6] Maastricht Univ, Care & Publ Hlth Res Inst, Fac Hlth Med & Life Sci, Dept Hlth Serv Res,Med Ctr, Univ Singel 40, NL-6229 ER Maastricht, Netherlands
[7] Isala Hosp, Dept Innovat & Sci, Epidemiol Unit, Dokter Deenweg 1, NL-8025 BP Zwolle, Netherlands
来源：
JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2025年 / 39卷 / 03期
关键词：
Lower extremity amputation; Mortality; Diabetes mellitus; FOOT ULCERS; NETHERLANDS; CARE; RISK;
D O I：
10.1016/j.jdiacomp.2025.108956
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background/objectives: To determine mortality rates after lower extremity amputation (LEA) in individuals with and without diabetes mellitus (DM). Methods: Retrospective, observational study using data from a database covering >99 % of the Dutch population. LEAs in 2016 were identified, and mortality data from 2016 to 2021 were analyzed. Study group 1 (SG1) included individuals with DM and LEA (DM+/LEA+) with two control groups (CG), DM+/LEA- (matched by age, sex, without (1a) and with (1b) socioeconomic status matching). Study group 2 (SG2) (DM+/LEA+) was composed after matching with non-DM individuals with LEA (DM-/LEA+ (2a)). Results: Among 5145 individuals with LEA in 2016, 56 % had DM. Five-year mortality was 61.2 % in SG1 (DM+/ LEA+) and 27.9 % in CG1a (DM+, LEA-) and 1b. Study group 2 (DM+/LEA+) had a 62.6 % five-year mortality rate, compared to 56.4 % in CG2a (DM-/LEA+). Conclusions: Mortality after LEA is high, especially in DM; socioeconomic status (SES) does not significantly impact mortality.
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页数：7
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