Medin, a link between vascular pathology and dementia?

被引：1

作者：

Altenburg, Ilse S. ^{[1
]}

Smets, Nina G. ^{[1
,2
,3
]}

Strijkers, Gustav J. ^{[1
,2
]}

Bakker, Erik N. T. P. ^{[1
,2
,3
]}

机构：

[1] Amsterdam Univ Med Ctr, Dept Biomed Engn & Phys, Amsterdam, Netherlands

[2] Amsterdam Cardiovasc Sci Res Inst, Amsterdam, Netherlands

[3] Amsterdam Neurosci Res Inst, Amsterdam, Netherlands

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2024年 / 44卷 / 12期

基金：

荷兰研究理事会;

关键词：

Amyloid beta deposition; CAA; dementia; medin; vascular pathology; LACTADHERIN; HYPERTENSION; DYSFUNCTION; ELASTIN; STROKE; BRAIN;

D O I：

10.1177/0271678X241289772

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Medin is a protein fragment derived from milk fat globule epidermal growth factor VIII (MFG-E8). Medin aggregates are present in the vessel wall of most subjects over 50 years of age. In this narrative review, we focus on the consequences of medin aggregation in relation to the development of dementia. Recent literature revealed medin as biomarker for dementia in CSF, specifically of a vascular subtype. Preclinical work showed that medin is associated with aging-related cerebral vascular dysfunction, vascular stiffening, hypertension, and. vascular amyloid beta deposition. These findings position medin as a potential mechanistic link between aging, vascular pathology and dementia.

引用

页码：1403 / 1408

页数：6

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