An overview of synthetic approaches and the potential bioactivity of different 1,2,3-triazole hybrids

被引：0

作者：

Zaghary, Wafaa A. ^{[1
]}

Anwar, Manal M. ^{[2
]}

El-Haggar, Radwan ^{[1
]}

Syam, Yasmin M. ^{[2
]}

Hashim, Alaa H. ^{[1
]}

机构：

[1] Helwan Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo 11795, Egypt

[2] Natl Res Ctr, Dept Therapeut Chem, Cairo 12622, Egypt

来源：

EGYPTIAN PHARMACEUTICAL JOURNAL | 2024年 / 23卷 / 02期

关键词：

1,2,3-Triazole; metal-catalyzed synthesis; metal-free synthesis; biological activities; CLICK CHEMISTRY; BIOLOGICAL EVALUATION; CONJUGATES SYNTHESIS; ONE-POT; TRIAZOLE; DESIGN; DERIVATIVES; METAL; COPPER; DENDRIMERS;

D O I：

10.4103/epj.epj_112_23

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1,2,3-Triazole is considered to be the lead structure for the discovery of many drug molecules. 1,2,3-Triazole has received considerable attention in the field of drug discovery due to its remarkable widespread biological potential. This work summarizes the current synthetic pathways adopted for the synthesis of diverse analogs of 1,2,3-triazole. It also introduces an overview of the latest advances in 1,2,3-triazole hybrid models with various pharmacological activities, their chemical structures, structure-activity relationships, and mechanisms of action.

引用

页码：157 / 183

页数：27

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