Migraines, the multiple sclerosis prodrome, and multiple sclerosis susceptibility

被引：0
作者：
Schoeps, Vinicius A. [2 ]
Smith, Jessica B. [3 ]
Langer-Gould, Annette [1 ,4 ]
机构：
[1] Southern Calif Permanente Med Grp, Los Angeles Med Ctr, Dept Neurol, 1505 N Edgemont,5Th Floor, Los Angeles, CA 90027 USA
[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA
[3] Southern Calif Permanente Med Grp, Dept Res & Evaluat, Pasadena, CA USA
[4] Kaiser Permanente Sch Med, Pasadena, CA USA
来源：
MULTIPLE SCLEROSIS JOURNAL | 2025年
关键词：
Multiple sclerosis; headache; migraine disorders; prodromal symptoms; HEALTH; EPIDEMIOLOGY; COMORBIDITY; ASSOCIATION; VALIDATION; DIAGNOSIS; HEADACHE; HISTORY; LESIONS; ONSET;
D O I：
10.1177/13524585251318293
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: Multiple studies identified an association between migraines and multiple sclerosis (MS).Objective: To investigate whether migraines increase MS risk or are part of the MS prodrome.Methods: Incident MS cases and matched controls completed structured interviews that included a detailed headache and MS history. Participants were classified as having migraines if they fulfilled the third edition of the International Classification of Headache Disorders criteria. The association between migraine onset concurrent with or before the first MS symptom/index date was estimated using multivariable logistic regression.Results: Among the 591 MS cases (70.6% females, 42.0% White), 21.2% developed migraines concurrent with or before the onset of MS compared to 18.7% of the 651 controls (70.4% females, 42.1% White, adjusted odds ratio (aOR) = 1.15, 95% confidence interval (CI) = 0.87-1.53). Migraine onset was more likely to occur either concurrently or 1 year before MS symptom onset/index date among MS cases (n = 18, 14.4%) than controls (n = 8, 6.6%; aOR = 2.52, 95% CI = 1.08-5.86, p = 0.032). However, not when restricted to only those with migraine onset before MS onset.Conclusion: Migraine was associated with an increased odds of MS only when co-occurrence was considered. These findings imply that migraines are part of the constellation of MS onset symptoms rather than a risk factor for or prodromal symptom of MS.
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页码：539 / 547
页数：9
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