Aspartame subacute exposure does not affect immune system of BALB/c mice following a tiered approach

被引：0

作者：

Farahi, Seyed Mostafa Moshirian ^{[1
]}

Forouzanfar, Fatemeh ^{[2
]}

Memar, Bahram ^{[3
]}

Rashidi, Roghayeh ^{[6
]}

Mahdipour, Ramin ^{[4
]}

Riahi-Zanjani, Bamdad ^{[1
]}

Sadeghi, Mahmood ^{[5
]}

机构：

[1] Mashhad Univ Med Sci, Med Toxicol Res Ctr, Sch Med, Mashhad, Iran

[2] Mashhad Univ Med Sci, Imam Reza Hosp, Fac Med, Clin Res Dev Unit, Mashhad, Iran

[3] Mashhad Univ Med Sci, Fac Med, Canc Res Ctr, Mashhad, Iran

[4] Mashhad Univ Med Sci, Sch Med, Dept Anat Sci & Cell Biol, Mashhad, Iran

[5] Birjand Univ Med Sci, Med Toxicol & Drug Abuse Res Ctr, Birjand, Iran

[6] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Iran

来源：

TISSUE & CELL | 2025年 / 93卷

关键词：

Aspartame; Immune system; HA; DTH; BALB/c mice; Immunotoxicity;

D O I：

10.1016/j.tice.2024.102657

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Background: The objective of the present study was to assess potential immunotoxic effects of aspartame in BALB/c mice. Methods: Aspartame was administered orally at 400 and 2000 mg/kg for two weeks (five days per week). Specific parameters of humoral and cellular immune responses including hemagglutinating antibody (HA) titer, cytokine production (IFN-gamma and IL-4 levels), delayed type hypersensitivity (DTH) response to SRBCs, histopathological examination of spleen and bone marrow, and T-lymphocyte proliferation in response to phytohemagglutinin-A (PHA) were evaluated. Results and conclusion: Aspartame at 400 and 2000 mg/kg did not significantly change hematological and histopathological parameters, HA titer, IFN-gamma and IL-4 levels, DTH, and lymphoproliferation responses (p > 0.05). Aspartame at 400 and 2000 mg/kg did not induce any noticeable effects in immune system parameters of mice after a 14-day feeding. Aspartame was found to be safe to BALB/c mice immune system.

引用

页数：8

共 25 条

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