cGAS-STING: mechanisms and therapeutic opportunities

被引：3

作者：

Zhang, Mengyuan ^{[1
,2
]}

Wu, Changxin ^{[3
]}

Lu, Defen ^{[4
]}

Wang, Xing ^{[1
,2
]}

Shang, Guijun ^{[3
,4
]}

机构：

[1] Shanxi Med Univ, Sch & Hosp Stomatol, Taiyuan 030001, Peoples R China

[2] Shanxi Prov Key Lab Oral Dis Prevent & New Mat, Taiyuan 030001, Peoples R China

[3] Shanxi Univ, Inst Biomed Sci, Key Lab Med Mol Cell Biol Shanxi Prov, Taiyuan 030006, Peoples R China

[4] Shanxi Agr Univ, Coll Life Sci, Taiyuan 030031, Peoples R China

来源：

SCIENCE CHINA-LIFE SCIENCES | 2025年 / 68卷 / 05期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

cGAS; STING; cGAMP; autoinhibition; activation; proton channel; CYCLIC GMP-AMP; DNA SENSOR CGAS; DOUBLE-STRANDED DNA; DI-GMP; STRUCTURAL BASIS; INNATE IMMUNITY; CRYSTAL-STRUCTURES; DINUCLEOTIDE; RECOGNITION; SYNTHASE;

D O I：

10.1007/s11427-024-2808-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The cGAS-STING pathway plays a crucial role in the innate immune system by detecting mislocalized double-stranded DNA (dsDNA) in the cytoplasm and triggering downstream signal transduction. Understanding the mechanisms by which cGAS and STING operate is vital for gaining insights into the biology of this pathway. This review provides a detailed examination of the structural features of cGAS and STING proteins, with a particular emphasis on their activation and inhibition mechanisms. We also discuss the novel discovery of STING functioning as an ion channel. Furthermore, we offer an overview of key agonists and antagonists of cGAS and STING, shedding light on their mechanisms of action. Deciphering the molecular intricacies of the cGAS-STING pathway holds significant promise for the development of targeted therapies aimed at maintaining immune homeostasis within both innate and adaptive immunity.

引用

页码：1309 / 1323

页数：15

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