First-line treatment of TAFRO syndrome with rituximab: a case report and literature review

被引:0
作者
Servati, Salar [1 ]
Mohammadi, Ida [2 ]
Firouzabadi, Shahryar Rajai [2 ]
机构
[1] Shahid Beheshti Univ Med Sci, Taleghani Gen Hosp, Dept Hematol, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Sch Med, Tehran, Iran
关键词
TAFRO syndrome; Castleman's disease; Rituximab; RETICULIN FIBROSIS/RENAL FAILURE; CASTLEMANS-DISEASE; CYCLOSPORINE-A; THROMBOCYTOPENIA; VARIANT; ANASARCA; FEVER;
D O I
10.1007/s00277-025-06327-9
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
TAFRO syndrome, a rare variant of Castleman's disease, is characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly. First-line treatments typically include immunosuppressive therapies such as cyclosporine A and tocilizumab. However, the use of rituximab as a first-line therapeutic agent remains under-reported. Here, we present the case of a 38-year-old female patient who initially exhibited lymphadenopathy and gradually developed the full spectrum of symptoms associated with TAFRO syndrome during her hospital stay. Rituximab, supplemented by prednisolone, was administered as the primary treatment. Over a follow-up period of five months, the patient's condition improved significantly, suggesting a positive therapeutic response. This case highlights the potential efficacy of rituximab as an alternative first-line therapy for TAFRO syndrome, offering a possible treatment option where standard therapeutic agents may not be available, suitable or effective.
引用
收藏
页码:3035 / 3046
页数:12
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