Puerarin Protects Myocardium From Ischaemia/Reperfusion Injury by Inhibiting Ferroptosis Through Downregulation of VDAC1

被引:0
|
作者
Hu, Fajia [1 ,2 ]
Hu, Tie [1 ,2 ]
He, Andi [1 ]
Yuan, Yong [1 ]
Wang, Xiuqi [1 ]
Zou, Chenchao [1 ]
Qiao, Yamei [3 ]
Xu, Huaihan [4 ]
Liu, Lanxiang [3 ]
Wang, Qun [4 ]
Liu, Jichun [2 ]
Lai, Songqing [1 ]
Huang, Huang [1 ,4 ]
机构
[1] Nanchang Univ, Jiangxi Med Coll, Affiliated Hosp 1, Inst Cardiovasc Surg Dis, Nanchang, Jiangxi, Peoples R China
[2] Nanchang Univ, Affiliated Hosp 2, Jiangxi Med Coll, Dept Cardiovasc Surg, Nanchang, Jiangxi, Peoples R China
[3] Nanchang Univ, Jiangxi Med Coll, Sch Pharm, Nanchang, Jiangxi, Peoples R China
[4] Nanchang Univ, Affiliated Hosp 1, Jiangxi Med Coll, Dept Cardiovasc Surg, Nanchang, Jiangxi, Peoples R China
关键词
ferroptosis; mitochondria; myocardial ischaemia-reperfusion injury; puerarin; VDAC1; ISCHEMIA-REPERFUSION INJURY;
D O I
10.1111/jcmm.70313
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Despite improvements in interventional techniques leading to faster myocardial reperfusion postmyocardial infarction, there has been a significant rise in the occurrence of myocardial ischaemia/reperfusion injury (MI/RI). A deeper understanding of the underlying mechanisms of MI/RI could offer a crucial approach to reducing myocardial damage and enhancing patient outcomes. This study examined the myocardial protective properties of puerarin (PUE) in the context of MI/RI using hypoxia/reoxygenation (H/R) or ischaemia/reperfusion (I/R) injury models were employed in H9c2 cells and C57BL/6 mice. Our findings demonstrate that pretreatment with PUE effectively mitigated cardiomyocyte ferroptosis, restored redox balance, preserved mitochondrial energy production and maintained mitochondrial function following MI/RI. Furthermore, these cardioprotective effects of PUE were found to be mediated by the downregulation of voltage-dependent anion channel 1 (VDAC1) protein. These data reveal a novel mechanism by which PUE inhibits MI/RI and reveal that this protective effect of PUE is dependent on the downregulation of VDAC1.
引用
收藏
页数:15
相关论文
共 50 条
  • [31] IRBESARTAN AMELIORATES APOPTOSIS AND PROTECTS FROM ISCHAEMIA/REPERFUSION INJURY
    Al-Amran, F. G.
    Hadi, N. R.
    Zamil, S. T.
    CARDIOLOGY, 2013, 126 : 79 - 79
  • [32] Costunolide Protects Myocardium From Ischemia Reperfusion Injury by Inhibiting Oxidative Stress Through Nrf2/Keap1 Pathway Activation
    Li, Weixin
    Luo, Yue
    Huang, Zhuqi
    Shen, Siyuan
    Dai, Chengyi
    Shen, Sirui
    Qi, Xiaoxiao
    Liang, Guang
    Luo, Wu
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2023, 82 (02) : 117 - 127
  • [33] Long-term oral resveratrol intake provides nutritional preconditioning against myocardial ischemia/reperfusion injury: Involvement of VDAC1 downregulation
    Liao, Zhangping
    Liu, Dan
    Tang, Lei
    Yin, Dong
    Yin, Shuhua
    Lai, Songqing
    Yao, Jianguo
    He, Ming
    MOLECULAR NUTRITION & FOOD RESEARCH, 2015, 59 (03) : 454 - 464
  • [34] Leptin, the obesity-related adipocytokine, protects the myocardium against ischaemia-reperfusion injury
    Smith, Christopher C. T.
    Mocanu, Mihaela M.
    Davidson, Sean M.
    Wynne, Abigail
    Simpkin, James
    Yellon, Derek M.
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2006, 40 (06) : 963 - 963
  • [35] Engineered Biomimetic Nanoplatform Protects the Myocardium Against Ischemia/Reperfusion Injury by Inhibiting Pyroptosis
    Wei, Yazhong
    Zhu, Minfang
    Li, Saiqi
    Hong, Ting
    Guo, Xiaoyu
    Li, Yongyong
    Liu, Yiqiong
    Hou, Xumin
    He, Bin
    ACS APPLIED MATERIALS & INTERFACES, 2021, 13 (29) : 33756 - 33766
  • [36] Ghrelin protects myocardium against ischemia/reperfusion injury via inhibiting myocardial apoptosis
    Soeki, T
    Fukuda, Y
    Koshiba, K
    Yamaguchi, K
    Kawano, T
    Yamada, H
    Wakatsuki, T
    Nomura, M
    Kangawa, K
    Ito, S
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 47 (04) : 308A - 308A
  • [37] ADENOSINE A1 RECEPTOR ACTIVATION CAN PROTECT THE MYOCARDIUM FROM ISCHAEMIA REPERFUSION INJURY POST REPERFUSION
    Bhandal, J.
    Hussain, A.
    Buckley, J.
    Maddock, H.
    HEART, 2018, 104 : A13 - A13
  • [38] A1 Adenosine receptor activation can protect the myocardium from ischaemia reperfusion injury post reperfusion
    Bhandal, J.
    Renshaw, D.
    Buckley, J.
    Maddock, H.
    Hussain, A.
    EUROPEAN HEART JOURNAL, 2017, 38 : 386 - 386
  • [39] Liproxstatin-1 Treatment Protects the Myocardium Against I-R Injury By Decreasing VDAC1 Levels and Increasing GPX4 Activity
    Feng Yansheng
    Madungwe, Ngonidzashe B.
    Tombo, Nathalie
    Liu Li
    Aliagan, Abdulhafiz
    Bopassa, Jean C.
    CIRCULATION RESEARCH, 2019, 125
  • [40] Atorvastatin Protects Myocardium Against Ischemia-Reperfusion Injury Through Inhibiting miR-199a-5p
    Zuo, YaBei
    Wang, YuZhao
    Hu, HaiJuan
    Cui, Wei
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2016, 39 (03) : 1021 - 1030