Biomass-Derived Cu-Catalyzed General C-X (X = C, N, O) Bond Formation: Carbenoid Insertion Reactions of C-H, N-H, O-H Bond and Late-stage Functionalization of Drug Molecules†

被引：0

作者：

Qin, Fuhua ^{[1
]}

Xue, Wenxuan ^{[1
]}

Tang, Conghui ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Hubei Key Lab Mat Chem & Serv Failure, Key Lab Mat Chem Energy Convers & Storage,Minist E, 1037 Luoyu Rd, Wuhan 430074, Hubei, Peoples R China

[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2025年 / 43卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Heterogeneous catalysis for organic synthesis; Copper catalysis; Carbene insertion reaction; Chitosan; Late-stage functionalization; 3d transition metals; Synthetic methods; Heterogeneous catalysis; COPPER; CHITOSAN; CARBON; RHODIUM(II); ACIDS; ALKYL;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The development of sustainable and efficient catalytic systems for the formation C-C, C-N, C-O bonds is a fundamental goal in modern synthetic chemistry. We present a biomass-derived Cu/Chitosan-800 catalyst that facilitates a range of carbenoid insertion reactions into C-H, N-H, and O-H bonds. This catalyst demonstrates remarkable activity, enabling the functionalization of diverse substrates, including the late-stage modification of drug molecules with up to 95% yield and good recyclability. Our findings highlight the catalyst's potential in advancing environmentally friendly chemical transformations, offering a promising tool for pharmaceutical synthesis and organic synthesis.

引用

页码：916 / 924

页数：9