The Therapeutic Potential of Pristimerin in Osteoarthritis: Mechanistic Insights from in vitro and in vivo Studies

被引:1
作者
Yin, Li [1 ,2 ,3 ,4 ]
Fan, Yong [1 ,2 ,3 ,4 ]
Zhong, Xugang [1 ,3 ,4 ]
Meng, Xiang [1 ,3 ,4 ]
He, Zeju [1 ,3 ,4 ]
Hong, Zheping [1 ,3 ,4 ]
Chen, Jihang [1 ,3 ,4 ]
Zhang, Qiong [5 ]
Kong, Mingxiang [1 ,3 ,4 ]
Wang, Jiao [1 ,3 ,4 ]
Tong, Yu [1 ,3 ,4 ]
Bi, Qing [1 ,2 ,3 ,4 ]
机构
[1] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Dept Sports Med, Hangzhou 310000, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Postgrad Training Base Alliance, Wenzhou 325000, Zhejiang, Peoples R China
[3] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Ctr Rehabil Med,Dept Orthoped, Hangzhou 310000, Zhejiang, Peoples R China
[4] Hangzhou Med Coll, Inst Sports Med & Osteoarthropathy, Hangzhou 310000, Zhejiang, Peoples R China
[5] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Dept Nursing, Hangzhou 310000, Zhejiang, Peoples R China
关键词
pristimerin; MAPK/NF-kappa B; chondrocyte inflammation; cartilage protection; osteoarthritis; RNA transcriptome sequencing; HAND OSTEOARTHRITIS; KNEE; HIP; EPIDEMIOLOGY; INDUCTION; COX-2; RISK;
D O I
10.2147/DDDT.S490388
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Objective: Osteoarthritis (OA), a degenerative disease marked by cartilage erosion and synovial proliferation, has led to an increased interest in natural plant-based compounds to slow its progression. Pristimerin(Pri), a triterpenoid compound derived from Tripterygium wilfordii, has demonstrated anti-inflammatory and antioxidant characteristics. This study explores the protective effects of Pri on OA and its potential mechanisms. Methods: In this study, we examined the impact of Pri on the expression of inflammatory factors and extracellular matrix(ECM) degradation induced by IL-1(3 in chondrocyte experiments. Bioinformatics analysis was then performed to investigate the potential signaling pathways involved in Pri's protective effects. Finally, the efficacy of Pri in reducing cartilage degradation was further evaluated in a destabilization of the medial meniscus (DMM) mouse model. Results: Utilizing bioinformatics analysis and in vitro studies, it was revealed that Pri inhibits the activation of NF-kappa B and MAPK signaling pathways, leading to the reversal of upregulated MMP-13 (matrix metalloproteinases-13), iNOS (inducible nitric oxide synthase), and COX-2(cyclooxygenase-2) elicited by IL-1(3 stimulation, as well as the partial restoration of Collagen-II levels. Furthermore, in a DMM mouse model, the group treated with Pri exhibited reduced cartilage degradation and slowed OA progression compared to the modeling group. Conclusion: This research highlights Pri as a potential therapeutic agent for delaying OA progression.
引用
收藏
页码:5445 / 5459
页数:15
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