The Role of Liquid Crystal Elastomers in Pioneering Biological Applications

Liquid crystal elastomers have shown an attractive potential for various biological applications due to their unique combination of mechanical flexibility and responsiveness to external stimuli. In this review, we will focus on a few examples of LCEs used with specific applications for biological/biomedical/environmental systems. So far, areas of innovation have been concentrating on the integration of LCEs to enhance stability under physiological conditions, ensure precise integration with biological systems, and address challenges related to optical properties and spatial control of deformation. However, several challenges and limitations must still be addressed to fully realize their potential in biomedical and environmental fields, and future research should focus on continuing to improve biocompatibility, response to the environment and chemical cues, mechanical properties, ensuring long-term stability, and establishing cost-effective production processes. So far, 3D/4D printing appears as a great promise to develop materials of high complexity, almost any shape, and high production output. However, researchers need to find ways to reduce synthesis costs to ensure that LCEs are developed using cost-effective production methods at a scale necessary for their specific applications' needs.