Quantitation and Error Measurements in Dose-Response Curves

被引:0
作者
Srinivasan, Bharath [1 ,2 ]
Lloyd, Matthew D. [3 ]
机构
[1] Robert Gordon Univ, Sch Pharm & Life Sci, Aberdeen AB10 7AQ, Scotland
[2] SUNNY Stony Brook Univ, Coll Arts & Sci, Dept Chem, Stony Brook, NY 11794 USA
[3] Univ Bath, Dept Life Sci, Bath BA2 7AY, England
关键词
DRUG DISCOVERY; VALIDATION; INHIBITORS; KINETICS;
D O I
10.1021/acs.jmedchem.5c00131
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:2052 / 2056
页数:5
相关论文
共 29 条
[1]   A general approach to modeling biphasic relationships [J].
Beckon, William ;
Parkins, Cary ;
Maximovich, Alexey ;
Beckon, Angela V. .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2008, 42 (04) :1308-1314
[2]  
CHENG Y, 1973, BIOCHEM PHARMACOL, V22, P3099
[3]  
Comley J., 2007, DRUG DISCOVERY, P36
[4]  
Copeland R. A., 2013, EVALUATION ENZYMEINH
[5]   The drug-target residence time model: a 10-year retrospective [J].
Copeland, Robert A. .
NATURE REVIEWS DRUG DISCOVERY, 2016, 15 (02) :87-95
[6]   An automated fitting procedure and software for dose-response curves with multiphasic features [J].
Di Veroli, Giovanni Y. ;
Fornari, Chiara ;
Goldlust, Ian ;
Mills, Graham ;
Koh, Siang Boon ;
Bramhall, Jo L. ;
Richards, Frances M. ;
Jodrell, Duncan I. .
SCIENTIFIC REPORTS, 2015, 5
[7]   Optimal Serial Dilutions Designs for Drug Discovery Experiments [J].
Donev, Alexander N. ;
Tobias, Randall D. .
JOURNAL OF BIOPHARMACEUTICAL STATISTICS, 2011, 21 (03) :484-497
[8]   Getting the Numbers Right in Medicinal Chemistry [J].
Ducho, Christian .
CHEMMEDCHEM, 2025, 20 (01)
[9]  
He LY, 2018, METHODS MOL BIOL, V1711, P351, DOI 10.1007/978-1-4939-7493-1_17
[10]   Accelerating the Validation of Endogenous On-Target Engagement and In Cellulo Kinetic Assessment for Covalent Inhibitors of KRASG12C in Early Drug Discovery [J].
Kantae, Vasudev ;
Polanski, Radoslaw ;
Lewis, Hilary J. ;
Haider, Afreen ;
Barratt, Derek ;
Srinivasan, Bharath .
ACS CHEMICAL BIOLOGY, 2022, 17 (08) :2366-2376