Topical Use of Ozonized Oils in the Treatment of Dermatoses: A Scoping Review

This scoping review identified topical skin applications of ozonated oils and their benefits in the treatment of dermatoses. The search for articles was carried out in the main sources: PubMed, Scopus, Cochrane, Embase, Lilacs, Web of Science and Google Scholar, in March 2024, without restrictions on language, time and study design, excluding reviews. Study selection was performed by two reviewers and discrepancies were resolved by a third reviewer. Data extraction, analysis and discussion were presented simultaneously by four reviewers. A total of 21 eligible studies were found, the majority of which were experimental studies (n = 16); the largest number of publications came from China (n = 7). Most studies dealt with skin lesions (n = 9), predominantly evaluating ozonated sunflower, olive and sesame oils (n = 5 for each oil), with only two studies evaluating formulations based on ozonated oils. The topical use of ozonated oils has demonstrated benefits for the treatment of dermatoses, but with little scientific evidence, requiring studies with more defined protocols, standardization of the type of ozonated oil, peroxide index and their dosages, as well as studies on the development of pharmaceutical formulations with ozonated oils as a vehicle and enhancers of active ingredients.