Targeting Arachidonic Acid Pathway with Natural Ingredients from Traditional Chinese Medicine for Cancer Prevention and Therapy

被引：0

作者：

Liu, Hui ^{[1
]}

Yu, Jiahui ^{[1
]}

Dong, Yajie ^{[2
]}

Rezeng, Caidan ^{[3
,4
]}

Li, Xiuming ^{[5
,6
]}

机构：

[1] Chengde Med Univ, Sch Tradit Chinese Med, Dept Prescript & TCM, Chengde, Hebei, Peoples R China

[2] Chengde Cty Hosp Tradit Chinese Med, Dept Pediat, Chengde, Peoples R China

[3] Qinghai Univ Nationalities, Sch Pharm, Xining, Peoples R China

[4] Minist Educ, Engn Res Ctr Pharmaceut Chinese Mat Med & New Drug, Beijing 100029, Peoples R China

[5] Chengde Med Univ, Affiliated Hosp, Dept Urol, Chengde 067000, Hebei, Peoples R China

[6] Hebei Key Lab Panvascular Dis, Chengde 067000, Hebei, Peoples R China

来源：

NATURAL PRODUCT COMMUNICATIONS | 2024年 / 19卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Arachidonic acid; traditional Chinese medicine; cancer therapy; Natural ingredients; NF-KAPPA-B; PROSTATE-CANCER; ELLAGIC ACID; EXPRESSION; INFLAMMATION; CELLS; CYTOCHROME-P450; CYCLOOXYGENASE; RESVERATROL; APIGENIN;

D O I：

10.1177/1934578X241290975

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the process of cancer transformation, arachidonic acid (AA) serves as an important metabolic pathway, contributing to the production of carcinogens by participating in the enzyme metabolic processes, like phospholipase A2, cyclooxygenases, cytochrome P450, and lipoxygenases. Chemopreventive drugs for various cancers have been developed from natural products that inhibit the AA pathway. Moreover, different monomers and components of traditional Chinese medicine (TCM) are widely suggested to be effective on preventing and treating cancer chemically. The present work focused on analyzed different therapeutic methods for natural ingredients from TCM, targeting the metabolic pathways of three enzymes within the AA pathway. Additionally, we summarized the substantial effect of TCM in effectively inhibiting tumors by regulating this pathway.

引用

页数：12

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