Efficacy of cabozantinib therapy for brain metastases from renal cell carcinoma

被引：4

作者：

Nakagawa, Takashi ^{[1
]}

Kijima, Toshiki ^{[1
]}

Imasato, Naoki ^{[1
]}

Nagoshi, Akihiko ^{[1
]}

Nakamura, Gaku ^{[1
]}

Uematsu, Toshitaka ^{[1
]}

Suzuki, Issei ^{[1
]}

Nishihara, Daisaku ^{[1
]}

Kamai, Takao ^{[1
]}

机构：

[1] Dokkyo Med Univ, Dept Urol, 880 Kitakobayashi, Shimotsuga, Tochigi 3210293, Japan

来源：

IJU CASE REPORTS | 2022年 / 5卷 / 04期

关键词：

brain metastases; cabozantinib; clear cell renal cell carcinoma; immunotherapy; radiotherapy; OPEN-LABEL; SUNITINIB; NIVOLUMAB; CANCER;

D O I：

10.1002/iju5.12459

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: We report two cases of renal cell carcinoma with brain metastases that showed remarkable responses to cabozantinib. Case presentation: (Case 1) A 70-year-old man with cT3aN0M0 clear cell renal cell carcinoma underwent radical nephrectomy and developed multiple brain metastases 2months postoperatively. The brain lesions regressed after stereotactic radiotherapy followed by ipilimumab plus nivolumab therapy, but a new brain metastasis that caused hemiplegia developed after 6months and showed no response to stereotactic radiotherapy. However, complete remission was achieved, and hemiplegia ceased within 2weeks of cabozantinib therapy. (Case 2) A 63-year-old man with cT3aN0M1 clear cell renal cell carcinoma and brain metastases underwent upfront cytoreductive nephrectomy. The brain lesions progressed rapidly 1month postoperatively. The lesions disappeared 2 weeks after cabozantinib plus nivolumab therapy. Conclusion: Cabozantinib, alone or in combination with immune checkpoint inhibitors, may be a viable option for clear cell renal cell carcinoma with brain metastases.

引用

页码：293 / 296

页数：4

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