Targeting PDGF/PDGFR Signaling Pathway by microRNA, lncRNA, and circRNA for Therapy of Vascular Diseases: A Narrow Review

被引:6
作者
Ma, Chao-Nan [1 ]
Shi, Shan-Rui [1 ]
Zhang, Xue-Ying [1 ]
Xin, Guo-Song [2 ]
Zou, Xiang [2 ]
Li, Wen-Lan [2 ]
Guo, Shou-Dong [1 ,2 ]
机构
[1] Shandong Second Med Univ, Inst Lipid Metab & Atherosclerosis, Sch Pharm, Weifang 261053, Peoples R China
[2] Harbin Univ Commerce, Engn Res Ctr Med, Sch Pharm, Harbin 150076, Peoples R China
基金
中国国家自然科学基金;
关键词
cardiovascular disease; non-coding RNA; platelet-derived growth factor; respiratory disease; vascular system; SMOOTH-MUSCLE-CELLS; ARTERIAL ENDOTHELIAL-CELLS; ORPHAN RECEPTOR-1 NOR-1; GROWTH-FACTOR-BETA; PDGF-BB; INDUCED PROLIFERATION; REGULATING INFLAMMATION; PULMONARY-HYPERTENSION; INHIBITS PROLIFERATION; VSMCS PROLIFERATION;
D O I
10.3390/biom14111446
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Despite the significant progress in diagnostic and therapeutic strategies, vascular diseases, such as cardiovascular diseases (CVDs) and respiratory diseases, still cannot be successfully eliminated. Vascular cells play a key role in maintaining vascular homeostasis. Notably, a variety of cells produce and secrete platelet-derived growth factors (PDGFs), which promote mitosis and induce the division, proliferation, and migration of vascular cells including vascular smooth muscle cells (SMCs), aortic SMCs, endothelial cells, and airway SMCs. Therefore, PDGF/PDGR receptor signaling pathways play vital roles in regulating the homeostasis of blood vessels and the onset and development of CVDs, such as atherosclerosis, and respiratory diseases including asthma and pulmonary arterial hypertension. Recently, accumulating evidence has demonstrated that microRNA, long-chain non-coding RNA, and circular RNA are involved in the regulation of PDGF/PDGFR signaling pathways through competitive interactions with target mRNAs, contributing to the occurrence and development of the above-mentioned diseases. These novel findings are useful for laboratory research and clinical studies. The aim of this article is to conclude the recent progresses in this field, particular the mechanisms of action of these non-coding RNAs in regulating vascular remodeling, providing potential strategies for the diagnosis, prevention, and treatment of vascular-dysfunction-related diseases, particularly CVDs and respiratory diseases.
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页数:28
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