Relationship between HE4 levels and metabolic parameters in PET of non-small cell lung cancer patients

被引：0

作者：

Yilmaz, Yigit ^{[1
]}

Ozercan, Mesut Melih ^{[2
]}

Ancin, Burcu ^{[2
,3
]}

Dikmen, Zeliha Gunnur ^{[4
]}

Tuncali, Meltem Caglar ^{[5
]}

Tuncel, Murat ^{[5
]}

Uysal, Serkan ^{[2
]}

Kumbasar, Ulas ^{[2
]}

Dikmen, Erkan ^{[2
]}

Dogan, Riza ^{[2
]}

机构：

[1] Ankara Private Guven Hosp, Dept Thorac Surg, Ankara, Turkiye

[2] Kirikkale Univ, Fac Med, Dept Thorac Surg, Kirikkale, Turkiye

[3] Burdur State Hosp, Dept Thorac Surg, Burdur, Turkiye

[4] Hacettepe Univ, Fac Med, Dept Clin Biochem, Ankara, Turkiye

[5] Hacettepe Univ, Fac Med, Dept Nucl Med, Ankara, Turkiye

来源：

BIOMARKERS IN MEDICINE | 2025年

关键词：

Human epididymis protein 4 (HE4); lung cancer; positron emission tomography (PET); standard uptake value (SUV); metabolic tumor volume (MTV); total lesion glycolysis (TLG); EPIDIDYMIS PROTEIN 4; TOTAL LESION GLYCOLYSIS; PROGNOSTIC VALUE; SERUM HE-4; FOLLOW-UP; METASTASIS; EXPRESSION; DIAGNOSIS; CA125;

D O I：

10.1080/17520363.2025.2471744

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: To investigate the relationship between serum human epididymis protein 4 (HE4) levels and metabolic parameters of positron emission tomography (PET) imaging in patients with lung cancer. Methods: Sixty non-small cell lung cancer (NSCLC) patients were included in this prospective study. Demographic information, smoking status, comorbid pathologies, preoperative HE4 levels, PET imaging metabolic parameters, disease stage and histopathology were recorded. Results: Significant positive correlations between serum HE4 levels and all the metabolic parameters were observed (p < 0.05). In univariate regression analyses, it was observed that high serum HE4 levels could indicate tumor be squamous cell carcinoma (SCC) (p = 0.029), advanced T stage (p = 0.041), and have high maximum standart uptake value (SUVmax) (p = 0.017). Conclusion: Serum HE4 levels can be used as a biomarker to predict tumor burden and metabolic activity for NSCLC patients. Although sufficient per power analysis, this study may have benefited from further expansion, and by patient heterogeneity in TNM stage and tumor histology, potentially affecting the assessment of parameter relationships.

引用

页码：259 / 265

页数：7

共 32 条

[1]

Samson P., Colditz G.A., Lung cancer: epidemiology and carcinogenesis, Shield’s General thoracic surgery, 2, pp. 2297-2325, (2019)

[2]

Bray F., Ferlay J., Soerjomataram I., Et al., Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA Cancer J Clin, 68, 6, pp. 394-424, (2018)

[3]

Pezzuto A., Trabalza Marinucci B., Ricci A., Et al., Predictors of respiratory failure after thoracic surgery: a retrospective cohort study with comparison between lobar and sub-lobar resection, J Int Med Res, 50, 6, (2022)

[4]

Pezzuto A., D'Ascanio M., Ricci A., Et al., Expression and role of p16 and GLUT1 in malignant diseases and lung cancer: a review, Thorac Cancer, 11, 11, pp. 3060-3070, (2020)

[5]

Choi S.I., Jang M.A., Jeon B.R., Et al., Clinical usefulness of human epididymis protein 4 in lung cancer, Ann Lab Med, 37, 6, pp. 526-530, (2017)

[6]

Dikmen Z.G., Colak A., Dogan P., Et al., Diagnostic performances of CA125, HE4, and ROMA index in ovarian cancer, Eur J Gynaecol Oncol, 36, 4, pp. 457-462, (2015)

[7]

Wang Y.M., Han C., Teng F., Et al., Predictive value of serum HE4 and CA125 concentrations for lymphatic metastasis of endometrial cancer, Int J Gynecol Obstet, 136, 1, pp. 58-63, (2017)

[8]

Zhong H., Qian Y.Y., Fang S.R., Et al., HE4 expression in lung cancer, a meta-analysis, Clin Chim Acta, 470, pp. 109-114, (2017)

[9]

Dikmen E., Gungor A., Dikmen Z.G., Et al., Diagnostic efficiency of HE4 and CYFRA 21–1 in patients with lung cancer, Uhod-Uluslar Hematol, 25, 1, pp. 44-50, (2015)

[10]

Kumbasar U., Dikmen Z.G., Yilmaz Y., Et al., Serum human epididymis protein 4 (HE4) as a diagnostic and follow-up biomarker in patients with non-small cell lung cancer, Uhod-Uluslar Hematol, 27, 3, pp. 137-142, (2017)

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