Efficacy of MET-targeting CAR T cells against glioblastoma patient-derived xenograft models

被引:0
|
作者
Anna Qin [1 ]
Anna Musket [1 ]
Benjamin Hilton [2 ]
Johanna Preiszner [3 ]
Giedre Krenciute [4 ]
Michael E. Berens [5 ]
Mingyao Ying [6 ]
Phillip R. Musich [1 ]
Qian Xie [1 ]
机构
[1] East Tennessee State University,Department of Biomedical Sciences, Quillen College of Medicine
[2] Greenwood Genetic Center,Cytogenetics Laboratory
[3] East Tennessee State University,Department of Pathology, Quillen College of Medicine
[4] St. Jude Children’s Research Hospital,Department of Bone Marrow Transplantation and Cellular Therapy
[5] Translational Genomics Research Institute,Clinical Genomics and Therapeutics Division
[6] Hugo W. Moser Research Institute at Kennedy Krieger,Department of Neurology
[7] Johns Hopkins University School of Medicine,Center of Excellence for Inflammation, Infectious Disease and Immunity
[8] East Tennessee State University,undefined
关键词
Cancer immunotherapy; Chimeric antigen receptor T cell therapy; Glioblastoma; Glioma stem cells; MET-targeted therapy;
D O I
10.1186/s12967-025-06475-6
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [21] Targeting Glioblastoma with CAR T Cells
    Poh, Alissa
    CANCER DISCOVERY, 2017, 7 (03) : 238 - 239
  • [22] Targeting CAR T cells to glioblastoma
    Sarah Crunkhorn
    Nature Reviews Drug Discovery, 2020, 19 (4) : 238 - 238
  • [23] Antitumor effects of intracranial injection of B7-H3-targeted Car-T and Car-Nk cells in a patient-derived glioblastoma xenograft model
    Tachi, Tetsuro
    Kijima, Noriyuki
    Kuroda, Hideki
    Ikeda, Syunya
    Murakami, Koki
    Nakagawa, Tomoyoshi
    Yaga, Moto
    Nakagawa, Kanji
    Utsugi, Reina
    Hirayama, Ryuichi
    Okita, Yoshiko
    Kagawa, Naoki
    Kishima, Haruhiko
    Imai, Chihaya
    Hosen, Naoki
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2024, 73 (12)
  • [24] Efficacy of Podoplanin-CAR-T Cells inex vivo Patient Derived Glioblastoma Organoidsl
    Diener, L.
    Goedert, N.
    Schulz, T.
    Monoranu, C.
    Ernestus, R.
    Hagemann, C.
    Lohr, M.
    Nerreter, T.
    Dufner, V
    NEURO-ONCOLOGY, 2022, 24
  • [25] A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma
    Stringer, Brett W.
    Day, Bryan W.
    D'Souza, Rochelle C. J.
    Jamieson, Paul R.
    Ensbey, Kathleen S.
    Bruce, Zara C.
    Lim, Yi Chieh
    Goasdoue, Kate
    Offenhauser, Carolin
    Akgul, Seckin
    Allan, Suzanne
    Robertson, Thomas
    Lucas, Peter
    Tollesson, Gert
    Campbell, Scott
    Winter, Craig
    Do, Hongdo
    Dobrovic, Alexander
    Inglis, Po-Ling
    Jeffree, Rosalind L.
    Johns, Terrance G.
    Boyd, Andreww
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [26] A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma
    Brett W. Stringer
    Bryan W. Day
    Rochelle C. J. D’Souza
    Paul R. Jamieson
    Kathleen S. Ensbey
    Zara C. Bruce
    Yi Chieh Lim
    Kate Goasdoué
    Carolin Offenhäuser
    Seçkin Akgül
    Suzanne Allan
    Thomas Robertson
    Peter Lucas
    Gert Tollesson
    Scott Campbell
    Craig Winter
    Hongdo Do
    Alexander Dobrovic
    Po-Ling Inglis
    Rosalind L. Jeffree
    Terrance G. Johns
    Andrew W. Boyd
    Scientific Reports, 9
  • [27] Characterization of patient-derived xenograft (PDX) models to evaluate clinical and therapeutic responses of glioblastoma multiforme
    Remonde, Dioval A.
    Carlson, Brett L.
    Schroeder, Mark A.
    Armstrong, Brock
    Peng, Sen
    Evers, Lisa
    Decker, Paul A.
    Passow, Jeanette Eckel
    Berens, Michael E.
    Tran, Nhan L.
    Jenkins, Robert B.
    Sarkaria, Jann N.
    CANCER RESEARCH, 2015, 75
  • [28] CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells
    Han, Jianfeng
    Chu, Jianhong
    Chan, Wing Keung
    Zhang, Jianying
    Wang, Youwei
    Cohen, Justus B.
    Victor, Aaron
    Meisen, Walter H.
    Kim, Sung-hak
    Grandi, Paola
    Wang, Qi-En
    He, Xiaoming
    Nakano, Ichiro
    Chiocca, E. Antonio
    Glorioso, Joseph C., III
    Kaur, Balveen
    Caligiuri, Michael A.
    Yu, Jianhua
    SCIENTIFIC REPORTS, 2015, 5
  • [29] CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells
    Jianfeng Han
    Jianhong Chu
    Wing Keung Chan
    Jianying Zhang
    Youwei Wang
    Justus B. Cohen
    Aaron Victor
    Walter H. Meisen
    Sung-hak Kim
    Paola Grandi
    Qi-En Wang
    Xiaoming He
    Ichiro Nakano
    E. Antonio Chiocca
    Joseph C. Glorioso III
    Balveen Kaur
    Michael A. Caligiuri
    Jianhua Yu
    Scientific Reports, 5
  • [30] Development and characterization of a panel of orthotopic glioblastoma multiforme (GBM) patient-derived xenograft (PDX) mouse models for drug efficacy evaluation
    Nielsen, Carsten H.
    Alfsen, Maria Z.
    Wick, Michael J.
    Rundle, Melissa
    Gudbergsson, Johann M.
    Jensen, Mette M.
    Kristensen, Lotte K.
    Juul, Mark U.
    Papadopoulos, Kyriakos P.
    Kjaer, Andreas
    CANCER RESEARCH, 2019, 79 (13)