Intraosseous Delivery of Mesenchymal Stem Cells for the Treatment of Bone and Hematological Diseases

被引:1
作者
Artamonov, Mikhail Yu. [1 ]
Sokov, Evgeniy L. [2 ]
机构
[1] Penn Med Princeton Hlth, Plainsboro, NJ 08536 USA
[2] Peoples Friendship Univ, Dept Algol & Rehabil, Moscow 117198, Russia
关键词
mesenchymal stem cells (MSC); intraosseous delivery; bone marrow niche; tissue regeneration; osteogenesis; immunomodulation; bone-related disorders; MSC retention; regenerative medicine; STROMAL CELLS; REGENERATIVE MECHANISMS; CANINE MODEL; HYPOXIA; MSCS; DIFFERENTIATION; PROLIFERATION; IMPACT; BRAIN;
D O I
10.3390/cimb46110752
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mesenchymal stem cells are used most in regenerative medicine due to their capacities in differentiation and immune modulation. The intraosseous injection of MSC into the bone has been recommended because of expected outcomes for retention, bioavailability, and enhanced therapeutic efficacy, particularly in conditions involving the bone, such as osteoporosis and osteonecrosis. A review of the intraosseous delivery of mesenchymal stem cells in comparison with intravenous and intra-arterial delivery methods will be subjected to critical examination. This delivery mode fares better regarding paracrine signaling and immunomodulation attributes, which are the cornerstone of tissue regeneration and inflammation reduction. The local complications and technical challenges still apply with this method. This study was more focused on further research soon to be conducted to further elucidate long-term safety and efficacy of intraosseous mesenchymal stem cell therapy. Though much has been achieved with very impressive progress in this field, it is worth noting that more studies need to be put into place so that this technique can be established as a routine approach, especially with further research in biomaterials, gene therapy, and personalized medicine.
引用
收藏
页码:12672 / 12693
页数:22
相关论文
共 98 条
  • [11] A safety study on intrathecal delivery of autologous mesenchymal stromal cells in rabbits directly supporting Phase I human trials
    Chen, Bingkun K.
    Staff, Nathan P.
    Knight, Andrew M.
    Nesbitt, Jarred J.
    Butler, Greg W.
    Padley, Douglas J.
    Parisi, Joseph E.
    Dietz, Allan B.
    Windebank, Anthony J.
    [J]. TRANSFUSION, 2015, 55 (05) : 1013 - 1020
  • [12] Repetitive Intrathecal Catheter Delivery of Bone Marrow Mesenchymal Stromal Cells Improves Functional Recovery in a Rat Model of Contusive Spinal Cord Injury
    Cizkova, Dasa
    Novotna, Ivana
    Slovinska, Lucia
    Vanicky, Ivo
    Jergova, Stanislava
    Rosocha, Jan
    Radonak, Jozef
    [J]. JOURNAL OF NEUROTRAUMA, 2011, 28 (09) : 1951 - 1961
  • [13] Stem cell therapy for acute myocardial infarction: Mesenchymal Stem Cells and induced Pluripotent Stem Cells
    Clavellina, Diana
    Balkan, Wayne
    Hare, Joshua M.
    [J]. EXPERT OPINION ON BIOLOGICAL THERAPY, 2023, 23 (10) : 951 - 967
  • [14] Dabrowska A., 2017, DISASTER EMERG MED J, V2, P19, DOI [10.5603/DEMJ.2017.0004, DOI 10.5603/DEMJ.2017.0004]
  • [15] Immunogenicity and Immunomodulatory Properties of Umbilical Cord Lining Mesenchymal Stem Cells
    Deuse, Tobias
    Stubbendorff, Mandy
    Tang-Quan, Karis
    Phillips, Neil
    Kay, Mark A.
    Eiermann, Thomas
    Phan, Thang T.
    Volk, Hans-Dieter
    Reichenspurner, Hermann
    Robbins, Robert C.
    Schrepfer, Sonja
    [J]. CELL TRANSPLANTATION, 2011, 20 (05) : 655 - 667
  • [16] Minimally Manipulated Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Systematic Review of Clinical Evidence
    Di Matteo, B.
    Vandenbulcke, F.
    Vitale, N. D.
    Iacono, F.
    Ashmore, K.
    Marcacci, M.
    Kon, E.
    [J]. STEM CELLS INTERNATIONAL, 2019, 2019
  • [17] Knee Intraosseous Injections: A Systematic Review of Clinical Evidence of Different Treatment Alternatives
    Di Matteo, Berardo
    Polignano, Alberto
    Onorato, Francesco
    La Porta, Agostino
    Iacono, Francesco
    Bonanzinga, Tommaso
    Raspugli, Giovanni
    Marcacci, Maurilio
    Kon, Elizaveta
    [J]. CARTILAGE, 2021, 13 (1_SUPPL) : 1165S - 1177S
  • [18] Cellular Reparative Mechanisms of Mesenchymal Stem Cells for Retinal Diseases
    Ding, Suet Lee Shirley
    Kumar, Suresh
    Mok, Pooi Ling
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (08)
  • [19] Intranasal Administration of Human MSC for Ischemic Brain Injury in the Mouse: In Vitro and In Vivo Neuroregenerative Functions
    Donega, Vanessa
    Nijboer, Cora H.
    Braccioli, Luca
    Slaper-Cortenbach, Ineke
    Kavelaars, Annemieke
    van Bel, Frank
    Heijnen, Cobi J.
    [J]. PLOS ONE, 2014, 9 (11):
  • [20] Recent progress of Bioinspired Hydrogel-based delivery system for endometrial repair
    Dong, Rong
    Ma, Saihua
    Zhao, Xiaoli
    Wang, Baojuan
    Roy, Mridul
    Yao, Lu
    Xia, Tian
    Liu, Yanting
    [J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022, 10