Ozone Therapy on Wound Healing by American Cutaneous Leishmaniasis: Preliminary Study

American cutaneous leishmaniasis (ACL) is an endemic disease that greatly impacts public health. This study aims to evaluate the effects of ozone therapy to reduce the healing time of a wound caused by ACL. The research is a case report. The patient presented a single lesion in the fibular region of the right lower limb, which was ulcerated and had an irregular shape. Ozone was administered for 15 min through a bag at a concentration of 60 mg/L, once a week for 15 weeks. In each session, photographic records were taken to measure the injury area. The lesion regressed weekly as ozone applications occurred; initially, the area of the lesion was 11.481 pixels/cm2, which decreased to the penultimate session with an area of 1.024 pixels/cm2. From the fourth week onwards, the presence of epithelialized tissue was noted, and in the fourteenth week, the presence of dermis and the completely healed wound covered by epithelialized tissue and dermal tissue were established in the fifteenth week. We concluded that it is possible to reduce the healing time of ACL injuries through ozone therapy, but new studies should be carried out with more patients and a control group.