Hepatitis C: sociodemographic and clinical profile of patients treated with direct-acting antivirals in a pharmaceutical office

被引:0
作者
Pegoraro, Karem Aline [1 ]
Folador, Edson Luiz [2 ]
Bertolini, Dennis Armando [3 ]
Campagna, Angela Maria [4 ]
机构
[1] Secretaria Estado Saude Sao Paulo, Programa Posgrad Assistencia Farmaceut, Rua Rui Barbosa 1858, BR-85900040 Toledo, Parana, Brazil
[2] Univ Fed Paraiba, Ctr Biotecnol, Programa Posgrad Profiss, Joao Pessoa, Paraiba, Brazil
[3] Univ Estadual Maringa, Dept Anal Clin & Biomed, Maringa, Parana, Brazil
[4] Univ Estadual Maringa, Dept Farm, Maringa, Parana, Brazil
关键词
HCV; antivirals agents; direct-acting antivirals; pharmaceutical services; genotype; VIRUS-INFECTION; GLOBAL EPIDEMIOLOGY;
D O I
10.4025/actascihealthsci.v45i1.62343
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
To report the sociodemographic and clinical profile of patients treated with direct-action antivirals (DAAs). Patients infected with hepatitis C virus in current treatment were followed up in a pharmaceutical office. Sociodemographic, clinical and medicines uses characteristics were obtained. A total of 62 patients were enrolled, with a higher proportion of men, aged between 40 and 69 years, low schooling, and workers. Were predominant the HCV virus genotype 1 (45.2%) and 3 (48.4%), and 19.4% were cirrhotic. Of the referred comorbidities, stood out those diseases related to the cardiovascular system (19.8%), psychiatric disorders (17.6%), endocrine and metabolic disorders (14.5%). Co-infections represented 5.2%, and were distributed between acute hepatitis A (1.0%), chronic viral hepatitis B (2.1%), and HIV (2.1%). Previous or current use of licit / illicit substances was reported by 33.9% of patients. A significant difference was identified in the youngest age group (25 to 39 years, p = 0.02), with a lower average viral load compared to the other age groups. The pharmacotherapeutic follow-up carried out in the period resulted in 157 pharmaceutical consultations. Patients with hepatitis C using DDAs were mostly men, aged between 40 and 69 years. Type 3 HCV genotype was most frequently identified. The presence of cirrhosis and other comorbidities serves as an alert for health professionals in the implementation of public health policies.
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页数:9
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