Dynamics of liver cancer cellular taxa revealed through single-cell RNA sequencing: Advances and challenges

被引：1

作者：

Li, Wenxin ^{[1
,2
]}

He, Huisi ^{[1
,3
]}

Wang, Hongyang ^{[1
,4
]}

Wen, Wen ^{[1
,2
,4
]}

机构：

[1] Naval Med Univ, Mil Med Univ 2, Natl Ctr Liver Canc, Affiliated Hosp 3, Shanghai 200438, Peoples R China

[2] Naval Med Univ, Mil Med Univ 2, Dept Clin Lab Med, Affiliated Hosp 3, Shanghai 200438, Peoples R China

[3] Naval Med Univ, Mil Med Univ 2, Dept Oncol, Affiliated Hosp 3, Shanghai 200438, Peoples R China

[4] Key Lab Signaling Regulat & Targeting Therapy Live, Minist Educ, Shanghai 200438, Peoples R China

来源：

CANCER LETTERS | 2025年 / 611卷

基金：

中国国家自然科学基金;

关键词：

Single-cell RNA sequencing; Liver cancer; Heterogeneity; Tumor microenvironment; Precision medicine; SINUSOIDAL ENDOTHELIAL-CELLS; HEPATOCELLULAR-CARCINOMA; T-CELLS; LANDSCAPE; SEQ; EXPRESSION; ORIGIN;

D O I：

10.1016/j.canlet.2024.217394

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Liver cancer is a leading cause of death worldwide, representing a substantial public health challenge. The advent of single-cell RNA sequencing has significantly advanced our understanding of cellular dynamics from the onset of liver cancer to therapeutic intervention. This technology has unveiled profound insights into cancer heterogeneity and the tumor microenvironment (TME), enabling the identification of key molecular drivers and phenotypic landscapes of liver cancer at a single-cell resolution. This review highlights recent advancements in mapping functional cell subsets, phenotypic alterations, and the diversity of the TME. These insights are pivotal for advancing targeted therapies and developing prognostic tools. Moreover, this review covers the ongoing challenges and advances from tumor initiation to progression, offering a detailed perspective on advancing personalized treatment.

引用

页数：13

共 129 条

[1]

Affo S, 2021, CANCER CELL, V39, P866, DOI 10.1016/j.ccell.2021.03.012

[2] A human liver cell atlas reveals heterogeneity and epithelial progenitors [J].

Aizarani, Nadim ;

Saviano, Antonio ;

Sagar ;

Mailly, Laurent ;

Durand, Sarah ;

Herman, Josip S. ;

Pessaux, Patrick ;

Baumert, Thomas F. ;

Gruen, Dominic .

NATURE, 2019, 572 (7768) :199-204

[3] Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defines hyperactivated Tregs as a potential therapeutic target [J].

Alvisi, Giorgia ;

Termanini, Alberto ;

Soldani, Cristiana ;

Portale, Federica ;

Carriero, Roberta ;

Pilipow, Karolina ;

Costa, Guido ;

Polidoro, Michela ;

Franceschini, Barbara ;

Malenica, Ines ;

Puccio, Simone ;

Lise, Veronica ;

Galletti, Giovanni ;

Zanon, Veronica ;

Colombo, Federico Simone ;

De Simone, Gabriele ;

Tufano, Michele ;

Aghemo, Alessio ;

Di Tommaso, Luca ;

Peano, Clelia ;

Cibella, Javier ;

Iannacone, Matteo ;

Roychoudhuri, Rahul ;

Manzo, Teresa ;

Donadon, Matteo ;

Torzilli, Guido ;

Kunderfranco, Paolo ;

Di Mitri, Diletta ;

Lugli, Enrico ;

Lleo, Ana .

JOURNAL OF HEPATOLOGY, 2022, 77 (05) :1359-1372

[4] Towards precision medicine in lymphoid malignancies [J].

Buhler, Marco M. ;

Martin-Subero, Jose, I ;

Pan-Hammarstrom, Qiang ;

Campo, Elias ;

Rosenquist, Richard .

JOURNAL OF INTERNAL MEDICINE, 2022, 292 (02) :221-242

[5] Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis [J].

Burdziak, Cassandra ;

Alonso-Curbelo, Direna ;

Walle, Thomas ;

Reyes, Jose ;

Barriga, FranciscoM. ;

Haviv, Doron ;

Xie, Yubin ;

Zhao, Zhen ;

Zhao, Chujun Julia ;

Chen, Hsuan-An ;

Chaudhary, Ojasvi ;

Masilionis, Ignas ;

Choo, Zi-Ning ;

Gao, Vianne ;

Luan, Wei ;

Wuest, Alexandra ;

Ho, Yu-Jui ;

Wei, Yuhong ;

Quail, Daniela F. ;

Koche, Richard ;

Mazutis, Linas ;

Chaligne, Ronan ;

Nawy, Tal ;

Lowe, Scott W. ;

Pe'er, Dana .

SCIENCE, 2023, 380 (6645) :597-+

[6] The single-cell transcriptional landscape of mammalian organogenesis [J].

Cao, Junyue ;

Spielmann, Malte ;

Qiu, Xiaojie ;

Huang, Xingfan ;

Ibrahim, Daniel M. ;

Hill, Andrew J. ;

Zhang, Fan ;

Mundlos, Stefan ;

Christiansen, Lena ;

Steemers, Frank J. ;

Trapnell, Cole ;

Shendure, Jay .

NATURE, 2019, 566 (7745) :496-+

[7] High-throughput Microwell-seq 2.0 profiles massively multiplexed chemical perturbation [J].

Chen, Haide ;

Liao, Yuan ;

Zhang, Guodong ;

Sun, Zhongyi ;

Yang, Lei ;

Fang, Xing ;

Sun, Huiyu ;

Ma, Lifeng ;

Fu, Yuting ;

Li, Jingyu ;

Guo, Qile ;

Han, Xiaoping ;

Guo, Guoji .

CELL DISCOVERY, 2021, 7 (01)

[8] The role of bone marrow-derived cells in the origin of liver cancer revealed by single-cell sequencing [J].

Chen, Lu ;

Yi, Xianfu ;

Guo, Piao ;

Guo, Hua ;

Chen, Ziye ;

Hou, Chunyu ;

Qi, Lisha ;

Wang, Yongrong ;

Li, Chengwen ;

Liu, Peng ;

Liu, Yucun ;

Xu, Yuanfu ;

Zhang, Ning .

CANCER BIOLOGY & MEDICINE, 2020, 17 (01) :142-+

[9] Report of cancer incidence and mortality in China, 2010 [J].

Chen, Wanqing ;

Zheng, Rongshou ;

Zhang, Siwei ;

Zhao, Ping ;

Zeng, Hongmei ;

Zou, Xiaonong .

ANNALS OF TRANSLATIONAL MEDICINE, 2014, 2 (07)

[10] Comprehensive molecular classification predicted microenvironment profiles and therapy response for hepatocellular carcinoma [J].

Chen, Yihong ;

Deng, Xiangying ;

Li, Yin ;

Han, Ying ;

Peng, Yinghui ;

Wu, Wantao ;

Wang, Xinwen ;

Ma, Jiayao ;

Hu, Erya ;

Zhou, Xin ;

Shen, Edward ;

Zeng, Shan ;

Cai, Changjing ;

Qin, Yiming ;

Shen, Hong .

HEPATOLOGY, 2024, 80 (03) :536-551

← 1 2 3 4 5 6 7 8 9 10 →