G Protein-Coupled Receptors in Skin Aging

被引：0
作者：
Cheung, Suet Ting [1 ,2 ]
Do, Yelim [1 ,2 ]
Kim, Eunah [1 ,2 ]
Rella, Antonella [3 ]
Goyarts, Earl [3 ]
Pernodet, Nadine [3 ,4 ]
Wong, Yung Hou [1 ,2 ,5 ,6 ]
机构：
[1] Hong Kong Univ Sci & Technol, Div Life Sci, Clear Water Bay, Hong Kong, Peoples R China
[2] Hong Kong Univ Sci & Technol, Biotechnol Res Inst, Hong Kong, Peoples R China
[3] Estee Lauder Co, Res & Dev, New York, NY USA
[4] Estee Lauder Res Labs, Melville, NY USA
[5] Hong Kong Univ Sci & Technol, Mol Neurosci Ctr, State Key Lab Mol Neurosci, Hong Kong, Peoples R China
[6] Hong Kong Univ Sci & Technol, Ctr Aging Sci, Hong Kong, Peoples R China
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2025年 / 145卷 / 04期
关键词：
G protein-coupled receptors; Inflammatory skin disease; Photoaging; Skin aging; CORTICOTROPIN-RELEASING HORMONE; CALCIUM-SENSING RECEPTOR; STIMULATES KERATINOCYTE PROLIFERATION; HUMAN-MELANOMA CELLS; GENE-RELATED PEPTIDE; PURINERGIC RECEPTORS; HUMAN MELANOCYTES; ANGIOTENSIN-II; ULTRASTRUCTURAL-LOCALIZATION; EPIDERMAL DIFFERENTIATION;
D O I：
10.1016/j.jid.2024.06.1288
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Skin aging is a complex biological process affected by a cutaneous functions through the modulations of signaling pathways and responses. Expressed in various cell types and skin tissue layers, G protein-coupled receptors (GPCRs) play a vital role in regulating skin aging. We have cataloged 156 GPCRs expressed in the skin and reviewed their roles in skin aging, such as pigmentation, loss of elasticity, wrinkles, rough texture, and aging-associated skin disorders. By exploring the GPCRs found in the skin, it may be possible to develop new treatment regimens for agingassociated skin conditions using GPCR ligands.
引用
收藏
页码：749 / 765.e8
页数：25
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