Dasatinib-induced colitis in a patient with chronic myeloid leukaemia

被引：0

作者：

Gluch, Alexander Edmund ^{[1
,2
,3
]}

Subhaharan, Deloshaan ^{[1
,2
,4
]}

Pillai, Sooraj ^{[2
,3
]}

Ramaswamy, Pradeep Kakkadasam ^{[1
,2
]}

机构：

[1] Gold Coast Univ Hosp, Dept Digest Hlth, Gold Coast, Australia

[2] Gold Coast Hosp & Hlth Serv, Southport, Qld, Australia

[3] Gold Coast Univ Hosp, Dept Pathol, Gold Coast, Australia

[4] Griffith Univ, Gold Coast, Qld, Australia

来源：

BMJ CASE REPORTS | 2025年 / 18卷 / 01期

关键词：

Chronic Myeloid Leukaemia; Dasatinib; Inflammatory bowel disease; Endoscopy; SEVERE HEMORRHAGIC COLITIS; PHASE;

D O I：

10.1136/bcr-2024-263646

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dasatinib is a common treatment for chronic myeloid leukaemia with numerous side effects including gastrointestinal. We report a woman in her 50s who presented with haematochezia, weight loss and a positive faecal occult blood test. She was being treated for chronic myeloid leukaemia with dasatinib without the use of any concurrent medications, including non-steroidal anti-inflammatory drugs. Initial colonoscopy demonstrated moderate patchy left-sided inflammation, with biopsies revealing mild chronic inflammation and prominent eosinophilia. Dasatinib was subsequently ceased, and a repeat colonoscopy 3 months later demonstrated completely resolved inflammation both endoscopically and histologically.

引用

页数：3

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