Dimethoxytetramethyldisilane: overcoming the limitations of palladium-catalyzed C-H silacyclization of 2-iodobiphenyls

被引：0

作者：

Zhou, Zhengrui ^{[1
]}

Tan, Xuliang ^{[1
]}

Peng, Shuyun ^{[1
]}

Liang, Yun ^{[1
]}

Yang, Yuan ^{[1
]}

机构：

[1] Hunan Normal Univ, Key Lab Chem Biol & Tradit Chinese Med Res, Key Lab Assembly & Applicat Organ Funct Mol Hunan, Minist Educ,Natl & Local Joint Engn Lab New Petro, Changsha 410081, Hunan, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2025年 / 12卷 / 14期

基金：

中国国家自然科学基金;

关键词：

SILYLATION; SILYLENE; SILICON; DIMETHYLSILYLENE; CYCLOADDITION; DISILYLATION; ACTIVATION; ACCESS; BONDS;

D O I：

10.1039/d5qo00249d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, a readily accessible silicon reagent (dimethoxytetramethyldisilane) has been developed for time-controlled palladium-catalyzed C-H silacyclization of 2-iodobiphenyls. This protocol enables divergent synthesis of dibenzooxadisilepines and dibenzosiloles in moderate to excellent yields by a process involving palladium-catalyzed disilylation, hydrolysis, condensation, and ring contraction. Notably, this reaction is compatible with a variety of substrates with electron-withdrawing groups, which overcomes the limitations of previous reports.

引用

页码：4031 / 4036

页数：6

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