Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior

被引：15

作者：

Barron, Jerika J. ^{[1
,2
]}

Mroz, Nicholas M. ^{[2
,3
]}

Taloma, Sunrae E. ^{[4
,5
,6
]}

Dahlgren, Madelene W. ^{[3
,7
]}

Ortiz-Carpena, Jorge F. ^{[3
]}

Keefe, Matthew G. ^{[1
,8
]}

Escoubas, Caroline C. ^{[1
]}

Dorman, Leah C. ^{[1
,9
]}

Vainchtein, Ilia D. ^{[1
]}

Chiaranunt, Pailin ^{[1
,3
]}

Kotas, Maya E. ^{[10
]}

Nowakowski, Tomasz J. ^{[1
,11
,12
]}

Bender, Kevin J. ^{[5
,6
]}

Molofsky, Ari B. ^{[3
]}

Molofsky, Anna V. ^{[1
,5
]}

机构：

[1] Univ Calif San Francisco, Weill Inst Neurosci, Dept Psychiat & Behav Sci, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Biomed Sci Grad Program, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94158 USA

[4] Univ Calif San Francisco, Neurosci Grad Program, San Francisco, CA 94158 USA

[5] Univ Calif San Francisco, Kavli Inst Fundamental Neurosci, San Francisco, CA 94158 USA

[6] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA

[7] Lund Univ, Dept Expt Med Sci, Lung Biol, Lund, Sweden

[8] Univ Calif San Francisco, Dev & Stem Cell Biol Grad Program, San Francisco, CA 94158 USA

[9] Chan Zuckerberg Biohub, San Francisco, CA 94158 USA

[10] Univ Calif San Francisco, Dept Med, Div Pulm Crit Care Allergy & Sleep Med, San Francisco, CA 94158 USA

[11] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94158 USA

[12] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94158 USA

来源：

SCIENCE | 2024年 / 386卷 / 6721期

基金：

美国国家科学基金会;

关键词：

INTERFERON-GAMMA; TYPE-2; DYSFUNCTION; INTERNEURONS; ACTIVATION; SURVIVAL; IMMUNITY; MEMORY; MICE;

D O I：

10.1126/science.adi1025

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The innate immune system shapes brain development and is implicated in neurodevelopmental diseases. It is critical to define the relevant immune cells and signals and their impact on brain circuits. In this work, we found that group 2 innate lymphoid cells (ILC2s) and their cytokine interleukin-13 (IL-13) signaled directly to inhibitory interneurons to increase inhibitory synapse density in the developing mouse brain. ILC2s expanded and produced IL-13 in the developing brain meninges. Loss of ILC2s or IL-13 signaling to interneurons decreased inhibitory, but not excitatory, cortical synapses. Conversely, ILC2s and IL-13 were sufficient to increase inhibitory synapses. Loss of this signaling pathway led to selective impairments in social interaction. These data define a type 2 neuroimmune circuit in early life that shapes inhibitory synapse development and behavior.

引用

页数：12

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