The Association of Asthma and Metabolic Dysfunction With Outcomes of Hospitalized Patients With COVID-19

被引：2

作者：

Vukoja, Marija ^{[1
]}

Tekin, Aysun ^{[2
]}

Parada, Nereida A. ^{[3
]}

Gray, JaVaughn C. ^{[4
]}

Mallouhi, Alan ^{[4
]}

Roddy, Tiana ^{[4
]}

Cartin-Ceba, Rodrigo ^{[5
,6
]}

Perkins, Nicholas E. ^{[7
]}

Belden, Katherine A. ^{[8
]}

Cheruku, Sreekanth ^{[9
,10
]}

Kaufman, Margit ^{[11
]}

Armaignac, Donna Lee ^{[12
]}

Christie, Amy B. ^{[13
]}

Lal, Amos ^{[14
]}

Zu, Yuanhao ^{[15
]}

Kumar, Vishakha ^{[16
]}

Walkey, Allen ^{[17
]}

Gajic, Ognjen ^{[14
]}

Kashyap, Rahul ^{[18
]}

Denson, Joshua L. ^{[3
]}

机构：

[1] Univ Novi Sad, Inst Pulm Dis Vojvodina, Fac Med, Dept Internal Med, Sremska Kamenica, Serbia

[2] Mayo Clin, Dept Internal Med, Div Nephrol & Hypertens, Rochester, MN USA

[3] Tulane Univ, Sch Med, John W Deming Dept Med, Sect Pulm Dis Crit Care & Environm Med, 1430 Tulane Ave, New Orleans, LA 70112 USA

[4] Tulane Univ, Sch Med, 1430 Tulane Ave, New Orleans, LA 70112 USA

[5] Mayo Clin, Dept Med, Div Pulm, Scottsdale, AZ USA

[6] Mayo Clin, Dept Crit Care Med, Scottsdale, AZ USA

[7] Univ South Carolina, Sch Med Greenville, Prisma Hlth, Greenville, SC USA

[8] Thomas Jefferson Univ Hosp, Div Infect Dis, Philadelphia, PA 19107 USA

[9] UT Southwestern Med Ctr, Dept Anesthesiol & Pain Management, Div Cardiothorac Anesthesiol, Dallas, TX USA

[10] UT Southwestern Med Ctr, Dept Anesthesiol & Pain Management, Div Crit Care Med, Dallas, TX USA

[11] Englewood Hlth, Englewood, NJ USA

[12] Baptist Hlth South Florida, Miami, FL USA

[13] Atrium Hlth Navicent, Dept Crit Care, Macon, GA USA

[14] Mayo Clin, Dept Med, Div Pulm & Crit Care Med, Rochester, MN USA

[15] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Biostat & Data Sci, New Orleans, LA USA

[16] Soc Crit Care Med, Mt Prospect, IL USA

[17] Boston Univ, Sch Med, Dept Med,Evans Ctr Implementat & Improvement Sci, Pulm Ctr,Div Pulm Allergy Crit Care & Sleep Med, Boston, MA 02118 USA

[18] Mayo Clin, Dept Anesthesiol & Perioperat Med, Rochester, MN USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2024年 / 12卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Asthma; COVID-19; Mortality; Obesity; Metabolic syndrome; RESPIRATORY ILLNESS UNIVERSAL; VIRAL-INFECTION; RISK; PREVALENCE; EPIDEMIOLOGY; SEVERITY;

D O I：

10.1016/j.jaip.2024.05.025

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

BACKGROUND: There have been conflicting results on the association of asthma with the severity of coronavirus disease 2019 (COVID-19). Poor metabolic health has been previously associated with both severe COVID-19 and inflammation in asthma. OBJECTIVES: To examine the association between asthma and COVID-19 outcomes and whether these associations are modified by metabolic syndrome. METHODS: We performed an international, observational cohort study of adult patients hospitalized for COVID-19 from February 2020 through October 2021. The primary outcome was hospital mortality. RESULTS: The study included 27,660 patients from 164 hospitals, 12,114 (44%) female, with a median (interquartile range) age of 63 years (51-75). After adjusting for age, sex, smoking, race, ethnicity, geographic region, and Elixhauser comorbidity index, we found that patients with asthma were not at greater risk of hospital death when compared with patients with no chronic pulmonary disease (controls) (adjusted odds ratio [aOR], 0.97; 95% CI, 0.90-1.04; P = .40). Patients with asthma, when compared with controls, required higher respiratory support identified by the need for supplemental oxygen (aOR, 1.07; 95% CI, 1.01-1.14; P = .02), high-flow nasal cannula or noninvasive mechanical ventilation (aOR, 1.06; 95% CI, 1.00-1.13; P = .04), and invasive mechanical ventilation (aOR, 1.09; 95% CI, 1.031.16; P = .003). Metabolic syndrome increased the risk of death in patients with asthma, but the magnitude of observed association was similar to controls in stratified analysis (interaction P value .24). CONCLUSIONS: In this international cohort of hospitalized COVID-19 patients, asthma was not associated with mortality but was associated with increased need for respiratory support. Although metabolic dysfunction was associated with increased risks in COVID-19, these risks were similar for patients with or without asthma. (c) 2024 American Academy of Allergy, Asthma & Immunology

引用

页码：2390 / 2398.e7

页数：16

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