Heteroaryl-Directed Iridium-Catalyzed Enantioselective C-H Alkenylations of Secondary Alcohols

被引：0

作者：

Mao, Wenbin ^{[1
]}

Robertson, Craig M. ^{[1
]}

Bower, John F. ^{[1
]}

机构：

[1] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2024年 / 147卷 / 01期

基金：

欧洲研究理事会; 欧盟地平线“2020”;

关键词：

FUNCTIONALIZATION; AZAARENES;

D O I：

10.1021/jacs.4c16414

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Under iridium-catalyzed conditions, 2-aza-aryl-substituted secondary alcohols undergo C(sp3)-H addition reactions to alkynes to provide alkenylated tertiary alcohols. The processes occur with very high regio- and enantioselectivity. An analogous addition to styrene is shown to provide a prototype C(sp3)-H alkylation process. A mechanism based on directed aza-enolization of the reactant alcohol is proposed.

引用

页码：118 / 124

页数：7

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