Heteroaryl-Directed Iridium-Catalyzed Enantioselective C-H Alkenylations of Secondary Alcohols

被引：0
作者：
Mao, Wenbin [1 ]
Robertson, Craig M. [1 ]
Bower, John F. [1 ]
机构：
[1] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, England
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2024年 / 147卷 / 01期
基金：
欧盟地平线“2020”; 欧洲研究理事会;
关键词：
FUNCTIONALIZATION; AZAARENES;
D O I：
10.1021/jacs.4c16414
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Under iridium-catalyzed conditions, 2-aza-aryl-substituted secondary alcohols undergo C(sp3)-H addition reactions to alkynes to provide alkenylated tertiary alcohols. The processes occur with very high regio- and enantioselectivity. An analogous addition to styrene is shown to provide a prototype C(sp3)-H alkylation process. A mechanism based on directed aza-enolization of the reactant alcohol is proposed.
引用
收藏
页码：118 / 124
页数：7
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