The use of sugammadex in an infant with prolonged neuromuscular blockade

被引:3
作者
Kim, Hyunho [1 ]
机构
[1] Inje Univ, Coll Med, Sanggye Paik Hosp, Dept Anesthesiol & Pain Med, 1342 Dongil Ro, Seoul 01757, South Korea
来源
ANESTHESIA AND PAIN MEDICINE | 2022年 / 17卷 / 01期
关键词
Delayed emergence from anesthesia; infant; residual neuromuscular block; Rocuronium; Sugammadex; REMIMAZOLAM CNS 7056; PROCEDURAL SEDATION; FLUMAZENIL; EFFICACY; SAFETY; PHARMACOKINETICS; ANESTHESIA; MIDAZOLAM; PHARMACODYNAMICS; COLONOSCOPY;
D O I
10.17085/apm.21071
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background: Residual neuromuscular blockade (RNMB) is a frequent event after general anesthesia, which can lead to serious complications, such as upper airway obstruction. Sugammadex is useful in reversing RNMB. However, its use in infants has not yet been ap-proved by the Food and Drug Administration. Therefore, anesthesiologists can be hesitant use it, even in situations where no other choice is available. Case: A two-month-old baby presented to the hospital for umbilical polypectomy. At the end of the surgery, neostigmine was administered. Even after waiting for 30 min and injecting an additional dose of neostigmine, neuromuscular blockade was not adequately reversed. Eventually, sugammadex was administered, and spontaneous breathing returned. Conclusions: If there were no particular causes of delayed return to spontaneous breathing in infants, RNMB should be considered and reversal with sugammadex would be useful
引用
收藏
页码:52 / 56
页数:138
相关论文
共 54 条
[1]   Target-Controlled Infusion: A Mature Technology [J].
Absalom, Anthony R. ;
Glen, John B. ;
Zwart, Gerrit J. C. ;
Schnider, Thomas W. ;
Struys, Michel M. R. F. .
ANESTHESIA AND ANALGESIA, 2016, 122 (01) :70-78
[2]  
Acacia Pharma, 2021, BYFAVOTM (remimazolam): US prescribing information
[3]   A Placebo- and Midazolam-Controlled Phase I Single Ascending-Dose Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of Remimazolam (CNS 7056): Part I. Safety, Efficacy, and Basic Pharmacokinetics [J].
Antonik, Laurie J. ;
Goldwater, D. Ronald ;
Kilpatrick, Gavin J. ;
Tilbrook, Gary S. ;
Borkett, Keith M. .
ANESTHESIA AND ANALGESIA, 2012, 115 (02) :274-283
[4]   FLUMAZENIL - A REAPPRAISAL OF ITS PHARMACOLOGICAL PROPERTIES AND THERAPEUTIC EFFICACY AS A BENZODIAZEPINE ANTAGONIST [J].
BROGDEN, RN ;
GOA, KL .
DRUGS, 1991, 42 (06) :1061-1089
[5]   Recommendations for standards of monitoring during anaesthesia and recovery 2015: Association of Anaesthetists of Great Britain and Ireland [J].
Checketts, M. R. ;
Alladi, R. ;
Ferguson, K. ;
Gemmell, L. ;
Handy, J. M. ;
Klein, A. A. ;
Love, N. J. ;
Misra, U. ;
Morris, C. ;
Nathanson, M. H. ;
Rodney, G. E. ;
Verma, R. ;
Pandit, J. J. .
ANAESTHESIA, 2016, 71 (01) :85-93
[6]   Remimazolam tosilate in upper gastrointestinal endoscopy: A multicenter, randomized, non-inferiority, phase III trial [J].
Chen, Shao-Hui ;
Yuan, Tang-Mi ;
Zhang, Jiao ;
Bai, Hua ;
Tian, Ming ;
Pan, Chu-Xiong ;
Bao, Hong-Guang ;
Jin, Xiao-Ju ;
Ji, Fu-Hai ;
Zhong, Tai-Di ;
Wang, Qiang ;
Lv, Jian-Rui ;
Wang, Sheng ;
Li, Yu-Juan ;
Yu, Yong-Hao ;
Luo, Ai-Lin ;
Li, Xiang-Kui ;
Min, Su ;
Li, Lin ;
Zou, Xiao-Hua ;
Huang, Yu-Guang .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2021, 36 (02) :474-481
[7]  
Chen SH, 2020, AM J TRANSL RES, V12, P4594
[8]   Induction and maintenance of procedural sedation in adults: focus on remimazolam injection [J].
Chen, Weiyun ;
Chen, Shaohui ;
Huang, Yuguang .
EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 2021, 14 (04) :411-426
[9]  
CHERNIK DA, 1990, J CLIN PSYCHOPHARM, V10, P244
[10]  
Doi M., 2014, NIHONN RINSYO MASUI, V34, P860, DOI DOI 10.2199/JJSCA.34.860