The epigenetic impact of fatty acids as DNA methylation modulators

被引：1
作者：
Ediriweera, Meran Keshawa [1 ]
Sandamalika, W. M. Gayashani [2 ]
机构：
[1] Univ Colombo, Dept Biochem & Mol Biol, Fac Med, Kynsey Rd, Colombo, Sri Lanka
[2] Wayamba Univ Sri Lanka, Fac Livestock Fisheries & Nutr, Dept Aquaculture & Fisheries, Makandura, Sri Lanka
来源：
DRUG DISCOVERY TODAY | 2025年 / 30卷 / 02期
关键词：
fatty acids; DNA methylation; epigenetics; epi-drugs; FISH-OIL SUPPLEMENTATION; DIETARY SUPPLEMENTATION; SKELETAL-MUSCLE; GENE-EXPRESSION; PROMOTER; EXPOSURE; METHYLTRANSFERASE; IDENTIFICATION; INHIBITION; PREGNANCY;
D O I：
10.1016/j.drudis.2024.104277
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
DNA methylation is a key epigenetic mechanism that regulates gene expression. Fatty acids, the building blocks of many essential lipids, play a crucial role in various biological events. Aberrant acetylation and methylation profiles are linked to a number of non-communicable diseases. Various fatty acids have been identified as potential 'epi-drugs' because of their ability to correct aberrant acetylation and methylation profiles in a number of non-communicable diseases, enhancing the value of their biochemical properties. This review summarizes the effects of selected saturated and unsaturated fatty acids and fatty-acid-rich food items on disease-associated DNA methylation profiles, aiming to justify the classification of fatty acids as DNA methylation modulators.
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页数：11
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