Flagellin enhances shrimp antiviral immunity through the Shoc2/Erk/Stat/ Ficolin pathway

被引：0

作者：

Wang, Wei-Guang ^{[1
]}

Wei, Zhe ^{[1
]}

Wang, Xian-Wei ^{[1
,2
,3
]}

机构：

[1] Shandong Univ, Sch Life Sci, Shandong Prov Key Lab Anim Cells & Dev Biol, Qingdao 266237, Peoples R China

[2] Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China

[3] Shandong Univ, State Key Lab Microbial Technol, Qingdao 266237, Peoples R China

来源：

AQUACULTURE | 2025年 / 603卷

关键词：

FlaA; Ficolin; White spot syndrome virus (WSSV); Antiviral immunity; BACTERIAL FLAGELLIN; PENAEUS-MONODON; AQUACULTURE; ANTIBIOTICS; RECOGNITION; HEALTH;

D O I：

10.1016/j.aquaculture.2025.742415

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

Pathogenic infections, particularly viral and bacterial infections (such as white spot syndrome virus and vibrio species), have emerged more frequently with the increase in aquaculture density and environmental stress, resulting in significant economic losses for the shrimp industry. Bacterial flagellin A (FlaA), a pathogenassociated molecular pattern, activates nuclear factor-kappa beta and mitogen activated protein kinase signaling pathways in mammals through the Toll-like receptor 5, thereby triggering an inflammatory response. This study is the first to demonstrate that FlaA regulates the expression of the antiviral molecule ficolin through the Shoc2/Erk/Stat pathway, thereby enhancing antiviral capacity in shrimp. Our results indicate that FlaA induces antibacterial molecules and activates antiviral molecules, showcasing broad-spectrum immune-activating potential. These findings advance our understanding of the role of FlaA in host immunity and offer valuable insights for developing immune-modulatory antiviral strategies in aquaculture.

引用

页数：6

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