Role of Immune Cells in Mediating the Causal Effect of Gut Microbiota on Type 2 Diabetes

被引：0

作者：

Liu, Ruifang ^{[1
]}

Chai, Ruiting ^{[2
]}

Yang, Zhaoyang ^{[1
]}

Li, Candong ^{[1
]}

机构：

[1] Fujian Univ Tradit Chinese Med, Fuzhou, Peoples R China

[2] Guangzhou Univ Chinese Med, Guangzhou, Peoples R China

来源：

CURRENT MOLECULAR MEDICINE | 2025年

关键词：

Causal effects; Type; 2; diabetes; Gut microbiota; Immune cells; Mendelian randomization analysis; inverse-variance weighted (IVW); GLUCOSE; OBESITY;

D O I：

10.2174/0115665240322713241114051433

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background Previous studies have suggested that gut microbiota and immune system regulation have potential links with type 2 diabetes (T2D). However, the causal association between gut microbiota and T2D and whether immune cells mediate this interaction is unclear.Methods A two-sample, two-step Mendelian randomization (MR) study utilizing an initial inverse-variance weighted (IVW) method was performed to explore the causal impact of gut microbiota on T2D and the intermediary role of immune cells.Results The MR analysis assigned 4 gut microbiota and metabolic pathways that increase the risk of T2D (G_Prevotella, g_Anaerotruncus, g_Streptococcus.s_Streptococcus_parasanguinis, and the pathway of PANTO-PWY) and other 4 gut microbiota and metabolic pathways that have a protective effect against T2D (PWY-5667, PWY-6892, PWY-7221, and the bacterial g_Paraprevotella.s_Paraprevotella_clara). Furthermore, 17 immune cell traits were identified as associated with T2D. The finding from mediation MR analysis revealed that PANTO-PWY increases T2D risk via CD3 on HLA DR+ CD4+, whereas PWY-7221 reduces T2D risk through CD4 on CD4 Treg.Conclusion The research reveals a mediated causal link between the gut microbiota and T2D via immune cells.

引用

页数：10

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