Control and interplay of scaffold-biomolecule interactions applied to cartilage tissue engineering

被引:0
作者
Dupuy, Silouane [1 ,3 ]
Salvador, Jeremy [1 ,2 ,3 ]
Morille, Marie [1 ]
Noel, Daniele [3 ]
Belamie, Emmanuel [1 ,2 ]
机构
[1] Univ Montpellier, ICGM, CNRS, ENSCM, Montpellier, France
[2] PSL Res Univ, EPHE, F-75014 Paris, France
[3] Univ Montpellier, IRMB, INSERM, Montpellier, France
关键词
MESENCHYMAL STEM-CELLS; BONE MORPHOGENETIC PROTEIN-2; GROWTH-FACTOR-BETA; HORMONE-RELATED PROTEIN; CHONDROGENIC DIFFERENTIATION; ARTICULAR-CARTILAGE; IN-VITRO; PROGENITOR CELLS; CONTROLLED-RELEASE; COLLAGEN-BINDING;
D O I
10.1039/d5bm00049a
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Cartilage tissue engineering based on the combination of biomaterials, adult or stem cells and bioactive factors is a challenging approach for regenerative medicine with the aim of achieving the formation of a functional neotissue stable in the long term. Various 3D scaffolds have been developed to mimic the extracellular matrix environment and promote cartilage repair. In addition, bioactive factors have been extensively employed to induce and maintain the cartilage phenotype. However, the spatiotemporal control of bioactive factor release remains critical for maximizing the regenerative potential of multipotent cells, such as mesenchymal stromal cells (MSCs), and achieving efficient chondrogenesis and sustained tissue homeostasis, which are essential for the repair of hyaline cartilage. Despite advances, the effective delivery of bioactive factors is limited by challenges such as insufficient retention at the site of injury and the loss of therapeutic efficacy due to uncontrolled drug release. These limitations have prompted research on biomolecule-scaffold interactions to develop advanced delivery systems that provide sustained release and controlled bioavailability of biological factors, thereby improving therapeutic outcomes. This review focuses specifically on biomaterials (natural, hybrid and synthetic) and biomolecules (molecules, proteins, nucleic acids) of interest for cartilage engineering. Herein, we review in detail the approaches developed to maintain the biomolecules in scaffolds and control their release, based on their chemical nature and structure, through steric, non-covalent and/or covalent interactions, with a view to their application in cartilage repair.
引用
收藏
页码:1871 / 1900
页数:30
相关论文
共 158 条
  • [11] Rosenbaum A.J., Grande D.A., Dines J.S., The use of mesenchymal stem cells in tissue engineering: A global assessment, Organogenesis, 4, 1, pp. 23-27, (2008)
  • [12] Nejadnik H., Hui J.H., Choong E.P.F., Tai B.C., Lee E.H., Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study, Am. J. Sports Med., 38, 6, pp. 1110-1116, (2010)
  • [13] Uzieliene I., Bagdonas E., Hoshi K., Sakamoto T., Hikita A., Tachtamisevaite Z., Et al., Different phenotypes and chondrogenic responses of human menstrual blood and bone marrow mesenchymal stem cells to activin A and TGF-beta3, Stem Cell Res. Ther., 12, 1, (2021)
  • [14] Maumus M., Peyrafitte J.A., D'Angelo R., Fournier-Wirth C., Bouloumie A., Casteilla L., Et al., Native human adipose stromal cells: localization, morphology and phenotype, Int. J. Obes., 35, 9, pp. 1141-1153, (2011)
  • [15] Liu T.M., Martina M., Hutmacher D.W., Hui J.H., Lee E.H., Lim B., Identification of common pathways mediating differentiation of bone marrow- and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages, Stem Cells, 25, 3, pp. 750-760, (2007)
  • [16] Hennig T., Lorenz H., Thiel A., Goetzke K., Dickhut A., Geiger F., Et al., Reduced chondrogenic potential of adipose tissue derived stromal cells correlates with an altered TGFbeta receptor and BMP profile and is overcome by BMP-6, J. Cell Physiol., 211, 3, pp. 682-691, (2007)
  • [17] Loh Q.L., Choong C., Three-dimensional scaffolds for tissue engineering applications: role of porosity and pore size, Tissue Eng., Part B, 19, 6, pp. 485-502, (2013)
  • [18] Bruzauskaite I., Bironaite D., Bagdonas E., Bernotiene E., Scaffolds and cells for tissue regeneration: different scaffold pore sizes-different cell effects, Cytotechnology, 68, 3, pp. 355-369, (2016)
  • [19] Takahashi T., Ogasawara T., Asawa Y., Mori Y., Uchinuma E., Takato T., Et al., Three-dimensional microenvironments retain chondrocyte phenotypes during proliferation culture, Tissue Eng., 13, 7, pp. 1583-1592, (2007)
  • [20] Zhang X., Wu Y., Pan Z., Sun H., Wang J., Yu D., Et al., The effects of lactate and acid on articular chondrocytes function: Implications for polymeric cartilage scaffold design, Acta Biomater., 42, pp. 329-340, (2016)