Proton Pump Inhibitor Use and Its Association With Asthma: A Systematic Review and Meta-Analysis

被引：0

作者：

Bushi, Ganesh ^{[1
,2
]}

Khatib, Mahalaqua Nazli ^{[3
]}

Ballal, Suhas ^{[4
]}

Bansal, Pooja ^{[5
]}

Tomar, Balvir S. ^{[6
]}

Ashraf, Ayash ^{[7
]}

Ravi Kumar, M. ^{[8
]}

Sinha, Aashna ^{[9
]}

Rawat, Pramod ^{[10
,11
]}

Gaidhane, Abhay M. ^{[12
,13
]}

Sah, Sanjit ^{[14
,15
,16
]}

Serhan, Hashem Abu ^{[17
]}

Singh, Mahendra Pratap ^{[18
]}

Shabil, Muhammed ^{[19
,20
]}

机构：

[1] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara, India

[2] Global Ctr Evidence Synth, Evidence Policy & Learning, Chandigarh, India

[3] Datta Meghe Inst Higher Educ, Global Consortium Publ Hlth & Res, Div Evidence Synth, Wardha, India

[4] JAIN, Sch Sci, Dept Chem & Biochem, Bangalore, Karnataka, India

[5] Vivekananda Global Univ, Dept Allied Healthcare & Sci, Jaipur 303012, Rajasthan, India

[6] Nims Univ, Inst Pediat Gastroenterol & Hepatol, Jaipur, India

[7] Chandigarh Pharm Coll, Chandigarh Grp Coll, Mohali 140307, Punjab, India

[8] Raghu Engn Coll, Dept Chem, Visakhapatnam 531162, AP, India

[9] Uttaranchal Univ, Sch Appl & Life Sci, Div Res & Innovat, Dehra Dun 248007, Uttarakhand, India

[10] Graph Era, Dept Biotechnol, Dehra Dun 248002, India

[11] Graph Era Hill Univ, Dept Allied Sci, Haldwani, Uttaranchal, India

[12] Datta Meghe Inst HIgher Educ & Res, Jawaharlal Nehru Med Coll, Sch Epidemiol & Publ Hlth, Wardha, India

[13] Datta Meghe Inst Higher Educ, Global Hlth Acad, Sch Epidemiol & Publ Hlth, Wardha, India

[14] Dr D.Y Patil Vidyapeeth, Dr D Y Patil Med Coll Hosp & Res Ctr, Dept Paediat, Pune 411018, India

[15] Dr D Y Patil Vidyapeeth, Dr D Y Patil Dent Coll & Hosp, Dept Publ Hlth Dent, Pune 411018, India

[16] Korea Univ, Dept Med, Seoul, South Korea

[17] Hamad Med Corp, Dept Ophthalmol, Doha, Qatar

[18] Saveetha Univ, Saveetha Med Coll & Hosp, Saveetha Inst Med & Tech Sci, Ctr Global Hlth Res, Chennai, India

[19] Chandigarh Univ, Univ Ctr Res & Dev, Mohali, India

[20] AL Mustaqbal Univ, Med Labs Tech Dept, Hillah 51001, Iraq

来源：

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 2025年 / 2025卷 / 01期

关键词：

asthma; meta-analysis; proton pump inhibitors; systematic review; ACID-SUPPRESSIVE DRUGS; RISK; DISEASE; PREGNANCY; CHILDHOOD; COUNTRIES; EXPOSURE; ADULTS; TRENDS;

D O I：

10.1155/jcpt/6643853

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: Asthma is a prevalent chronic respiratory condition marked by airway inflammation and hyperresponsiveness, significantly impacting quality of life. Emerging evidence suggests a potential association between proton pump inhibitor (PPI) use and an increased risk of asthma. This systematic review and meta-analysis assessed the relationship between PPI use and the development or exacerbation of asthma. Methods: A systematic search of PubMed, Web of Science, and Embase databases was conducted, covering studies published from the inception of the database to July 12, 2024. Observational studies examining the association between PPI use and asthma risk were included. Two reviewers independently extracted data using Nested Knowledge software, with study quality assessed via the Newcastle-Ottawa Scale. A random-effects meta-analysis was performed, pooling odds ratios (ORs) and hazard ratios (HRs) to assess the association, with heterogeneity evaluated via the I2 statistic. Results: Fourteen studies, conducted between 2009 and 2024 and involving over 1.7 million participants, met the inclusion criteria. The pooled HR showed a 38% increased risk of asthma among PPI users compared to nonusers (HR, 1.38; 95% CI, 1.14-1.62). OR analysis indicated a 29% higher risk (OR, 1.29; 95% CI, 1.23-1.35). PPI users had an 81% higher risk compared to histamine H2 receptor antagonist (H2RA) users (HR, 1.81; 95% CI, 1.09-2.53), and asthma patients using PPIs were 61% more likely to experience exacerbations (OR, 1.61; 95% CI, 1.42-1.80). Conclusion: PPI use is associated with an increased risk of asthma. These findings underscore the need for cautious prescribing and further investigation into underlying mechanisms.

引用

页数：9

共 50 条

[1]

Pohan I.T., Tarigan A.P., Pandia P., Mutiara E., Role of Digital Education Through Smartphones in Improving Knowledge Among Asthma Patients: A Preliminary Study, Narrative Journal, 4, (2024)

[2]

McCracken J.L., Veeranki S.P., Ameredes B.T., Calhoun W.J., Diagnosis and Management of Asthma in Adults: A Review, JAMA, 318, pp. 279-290, (2017)

[3]

Bushi G., Khatib M.N., Balaraman A.K., Et al., Prevalence of Dual Use of Combustible Tobacco and E-Cigarettes Among Pregnant Smokers: A Systematic Review and Meta-Analysis, BMC Public Health, 24, (2024)

[4]

Ebmeier S., Thayabaran D., Braithwaite I., Benamara C., Weatherall M., Beasley R., Trends in International Asthma Mortality: Analysis of Data From the WHO Mortality Database From 46 Countries (1993–2012), Lancet, 390, pp. 935-945, (2017)

[5]

Akashanand A., Khatib M.N., Balaraman A.K., Et al., Patterns and Trends in Burden of Asthma and Its Attributable Risk Factors From 1990 to 2021 Among South Asian Countries: A Systematic Analysis for the Global Burden of Disease Study 2021, Journal of Asthma, pp. 1-12, (2025)

[6]

Hoogsteden H.C., Verhoeven G.T., Lambrecht B.N., Prins J.B., Airway Inflammation in Asthma and Chronic Obstructive Pulmonary Disease With Special Emphasis on the Antigen-Presenting Dendritic Cell: Influence of Treatment With Fluticasone Propionate, Clinical and Experimental Allergy, 29, pp. 116-124, (1999)

[7]

Lizzo J.M., Goldin J., Cortes S., Pediatric Asthma. StatPearls. Treasure Island (FL), (2024)

[8]

Haastrup P.F., Thompson W., Sondergaard J., Jarbol D.E., Side Effects of Long-Term Proton Pump Inhibitor Use: A Review, Basic and Clinical Pharmacology and Toxicology, 123, pp. 114-121, (2018)

[9]

Shin J.M., Sachs G., Pharmacology of Proton Pump Inhibitors, Current Gastroenterology Reports, 10, pp. 528-534, (2008)

[10]

Shin J.M., Munson K., Vagin O., Sachs G., The Gastric HK-ATPase: Structure, Function, and Inhibition, Pflügers Archiv: European Journal of Physiology, 457, pp. 609-622, (2009)

← 1 2 3 4 5 →