The Ferroxidase-Permease System for Transport of Iron Across Membranes: From Yeast to Humans

被引：0

作者：

Amadei, Matteo ^{[1
]}

Polticelli, Fabio ^{[2
]}

Musci, Giovanni ^{[3
]}

di Patti, Maria Carmela Bonaccorsi ^{[1
]}

机构：

[1] Sapienza Univ Rome, Dept Biochem Sci A Rossi Fanelli, I-00185 Rome, Italy

[2] Univ Roma Tre, Dept Sci, I-00146 Rome, Italy

[3] Univ Molise, Dept Biosci & Terr, I-86090 Pesche, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2025年 / 26卷 / 03期

关键词：

ferroxidase; multicopper oxidase; ceruloplasmin; hephaestin; ferroportin; Fet3; Ftr1; yeast; iron; copper; MULTICOPPER OXIDASE FET3P; GLYCOSYLPHOSPHATIDYLINOSITOL-ANCHORED CERULOPLASMIN; SACCHAROMYCES-CEREVISIAE; COPPER INCORPORATION; CANDIDA-ALBICANS; FUNCTIONAL-CHARACTERIZATION; MOLECULAR-MECHANISM; HUMAN FERROPORTIN; STRUCTURAL MODEL; PICHIA-PASTORIS;

D O I：

10.3390/ijms26030875

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transport of iron across the cell membrane is a tightly controlled process carried out by specific proteins in all living cells. In yeast and in mammals, a system formed by an enzyme with ferroxidase activity coupled to a membrane transporter supports iron uptake or iron efflux, respectively. Ferroxidase belongs to the family of blue multicopper oxidases, enzymes able to couple the one-electron oxidation of substrate(s) to full reduction of molecular oxygen to water. On the other hand, the permeases are widely different and are specific to Fe3+ and Fe2+ in yeast and multicellular organisms, respectively. This review will describe the yeast and human ferroxidase-permease systems, highlighting similarities and differences in structure, function and regulation of the respective protein components.

引用

页数：21

共 147 条

[61] Human ferroportin mediates proton-coupled active transport of iron [J].

Li, Shuang ;

Yang, Yihu ;

Li, Weikai .

BLOOD ADVANCES, 2020, 4 (19) :4758-4768

[62] Complex ATP7B mutation patterns in Wilson disease and evaluation of a yeast model for functional analysis of variants [J].

Li, Xiaojin ;

Zhang, Wei ;

Zhou, Donghu ;

Lv, Tingxia ;

Xu, Anjian ;

Wang, Hejing ;

Zhao, Xinyan ;

Zhang, Bei ;

Li, Yanmeng ;

Jia, Siyu ;

Wang, Yu ;

Wang, Xiaoming ;

Wu, Zhen ;

Duan, Weijia ;

Wang, Qianyi ;

Nan, Yuemin ;

Shang, Jia ;

Jiang, Wei ;

Chen, Yongpeng ;

Zheng, Sujun ;

Liu, Mei ;

Sun, Liying ;

You, Hong ;

Jia, Jidong ;

Ou, Xiaojuan ;

Huang, Jian .

HUMAN MUTATION, 2019, 40 (05) :552-565

[63] An X-ray structural study of human ceruloplasmin in relation to ferroxidase activity [J].

Lindley, PF ;

Card, G ;

Zaitseva, I ;

Zaitsev, V ;

Reinhammar, B ;

SelinLindgren, E ;

Yoshida, K .

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 1997, 2 (04) :454-463

[64] Spectroscopic and magnetic studies of human ceruloplasmin: Identification of a redox-inactive reduced Type 1 copper site [J].

Machonkin, TE ;

Zhang, HH ;

Hedman, B ;

Hodgson, KO ;

Solomon, EI .

BIOCHEMISTRY, 1998, 37 (26) :9570-9578

[65] The thermodynamics, kinetics, and molecular mechanism of intramolecular electron transfer in human ceruloplasmin [J].

Machonkin, TE ;

Solomon, EI .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (50) :12547-12560

[66] Spectroscopy and reactivity of the type 1 copper site in Fet3p from Saccharomyces cerevisiae:: Correlation of structure with reactivity in the multicopper oxidases [J].

Machonkin, TE ;

Quintanar, L ;

Palmer, AE ;

Hassett, R ;

Severance, S ;

Kosman, DJ ;

Solomon, EI .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (23) :5507-5517

[67] Role of External Loops of Human Ceruloplasmin in Copper Loading by ATP7B and Ccc2p [J].

Maio, Nunziata ;

Polticelli, Fabio ;

De Francesco, Giovanni ;

Rizzo, Gianluca ;

di Patti, Maria Carmela Bonaccorsi ;

Musci, Giovanni .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (27) :20507-20513

[68] The Structural Basis for Metal Ion Transport in the SLC11/NRAMP Family [J].

Manatschal, Cristina ;

Dutzler, Raimund .

CHIMIA, 2022, 76 (12) :1005-1010

[69] Immune cells and hepatocytes express glycosylphosphatidylinositol-anchored ceruloplasmin at their cell surface [J].

Marques, Liliana ;

Auriac, Anne ;

Willemetz, Alexandra ;

Banha, Joao ;

Silva, Bruno ;

Canonne-Hergaux, Francois ;

Costa, Luciana .

BLOOD CELLS MOLECULES AND DISEASES, 2012, 48 (02) :110-120

[70] Glial Cell Ceruloplasmin and Hepcidin Differentially Regulate Iron Efflux from Brain Microvascular Endothelial Cells [J].

McCarthy, Ryan C. ;

Kosman, Daniel J. .

PLOS ONE, 2014, 9 (02)

← 2 3 4 5 6 7 8 9 10 11 →