The Ferroxidase-Permease System for Transport of Iron Across Membranes: From Yeast to Humans

被引：0

作者：

Amadei, Matteo ^{[1
]}

Polticelli, Fabio ^{[2
]}

Musci, Giovanni ^{[3
]}

di Patti, Maria Carmela Bonaccorsi ^{[1
]}

机构：

[1] Sapienza Univ Rome, Dept Biochem Sci A Rossi Fanelli, I-00185 Rome, Italy

[2] Univ Roma Tre, Dept Sci, I-00146 Rome, Italy

[3] Univ Molise, Dept Biosci & Terr, I-86090 Pesche, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2025年 / 26卷 / 03期

关键词：

ferroxidase; multicopper oxidase; ceruloplasmin; hephaestin; ferroportin; Fet3; Ftr1; yeast; iron; copper; MULTICOPPER OXIDASE FET3P; GLYCOSYLPHOSPHATIDYLINOSITOL-ANCHORED CERULOPLASMIN; SACCHAROMYCES-CEREVISIAE; COPPER INCORPORATION; CANDIDA-ALBICANS; FUNCTIONAL-CHARACTERIZATION; MOLECULAR-MECHANISM; HUMAN FERROPORTIN; STRUCTURAL MODEL; PICHIA-PASTORIS;

D O I：

10.3390/ijms26030875

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transport of iron across the cell membrane is a tightly controlled process carried out by specific proteins in all living cells. In yeast and in mammals, a system formed by an enzyme with ferroxidase activity coupled to a membrane transporter supports iron uptake or iron efflux, respectively. Ferroxidase belongs to the family of blue multicopper oxidases, enzymes able to couple the one-electron oxidation of substrate(s) to full reduction of molecular oxygen to water. On the other hand, the permeases are widely different and are specific to Fe3+ and Fe2+ in yeast and multicellular organisms, respectively. This review will describe the yeast and human ferroxidase-permease systems, highlighting similarities and differences in structure, function and regulation of the respective protein components.

引用

页数：21

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