Anamorelin as a Therapeutic Option for Cancer Cachexia in Advanced Pancreatic Cancer: A Case Report Demonstrating Significant Weight Gain and Quality of Life Improvement

被引：1

作者：

Kan, Motoyasu ^{[1
,2
]}

Ogane, Yoshiki ^{[1
]}

Watabe, Kazuki ^{[1
]}

Takahashi, Tomoya ^{[1
]}

Sakai, Miho ^{[1
]}

Sekine, Yu ^{[1
]}

Yamada, Nana ^{[1
]}

Sugihara, Chihei ^{[1
]}

Ouchi, Mayu ^{[1
]}

Nagashima, Hiroki ^{[1
]}

Takahashi, Koji ^{[2
]}

Okitsu, Koichiro ^{[1
]}

Ohyama, Hiroshi ^{[1
]}

Ohno, Izumi ^{[2
]}

Kato, Naoya ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Gastroenterol, Chiba, Japan

[2] Chiba Univ, Grad Sch Med, Dept Oncol, Chiba, Japan

来源：

INTERNAL MEDICINE | 2025年

关键词：

Pancreatic cancer; Supportive care; Cancer cahexia; Ghrelin; Anamorelin; CELL LUNG-CANCER; DOUBLE-BLIND;

D O I：

10.2169/internalmedicine.4708-24

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cancer cachexia, which is characterized by weight loss and muscle weakness, is common in patients with pancreatic cancer. Anamorelin, a ghrelin receptor agonist, has shown potential for the management of cachexia in various cancers. We herein report a 64-year-old man with unresectable pancreatic cancer who experienced significant weight gain with anamorelin, allowing for continued chemotherapy and an improved quality of life. Despite disease progression, his response suggests the potential utility of anamorelin as a supportive therapy. Cachexia's complex metabolic changes make treatment difficult; however, anamorelin's appetite and weight gain effects highlight its possible role in managing cachexia in pancreatic cancer. Therefore, further research is required in this regard.

引用

页数：6

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