New directions for tetrazolium - gellan gum gel dosimeters
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作者:
Penev, Kalin, I
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Univ Western Ontario, Dept Chem & Biochem Engn, London, ON N5A 5B9, Canada
Modus Med Devices Inc, 1570 N Routledge Pk, London, ON N6H 5L6, CanadaUniv Western Ontario, Dept Chem & Biochem Engn, London, ON N5A 5B9, Canada
Penev, Kalin, I
[1
,2
]
Mequanint, Kibret
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Univ Western Ontario, Dept Chem & Biochem Engn, London, ON N5A 5B9, Canada
Univ Western Ontario, Biomed Engn Program, London, ON N6A 5B9, CanadaUniv Western Ontario, Dept Chem & Biochem Engn, London, ON N5A 5B9, Canada
Mequanint, Kibret
[1
,3
]
机构:
[1] Univ Western Ontario, Dept Chem & Biochem Engn, London, ON N5A 5B9, Canada
[2] Modus Med Devices Inc, 1570 N Routledge Pk, London, ON N6H 5L6, Canada
[3] Univ Western Ontario, Biomed Engn Program, London, ON N6A 5B9, Canada
Tetrazolium salt-based dosimeters are non-diffusing, gel dosimeters with excellent physical and chemical stability but with relatively low dose sensitivity and a dose rate dependence of the dose response. Both issues are tackled in this study by: (a) the introduction of a new tetrazolium salt with simple synthesis and dose response around 585 nm which may provide the pathway to more sensitive formulations and (b) producing gels with low gellan gum concentration, thus limiting the dose rate effects, and addition of thickening agents to restrain the liquid loss (syneresis) from the resulting gels.
机构:
Univ Western Ontario, Dept Chem & Biochem Engn, London, ON N6A 5B9, Canada
Modus Med Devices Inc, London, ON N6H 5L6, CanadaUniv Western Ontario, Dept Chem & Biochem Engn, London, ON N6A 5B9, Canada
Penev, Kalin I. I.
Mulligan, Matt
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London Reg Canc Program, London, ON N6A 5W9, CanadaUniv Western Ontario, Dept Chem & Biochem Engn, London, ON N6A 5B9, Canada
Mulligan, Matt
Mequanint, Kibret
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机构:
Univ Western Ontario, Dept Chem & Biochem Engn, London, ON N6A 5B9, Canada
Univ Western Ontario, Biomed Engn Grad Program, London, ON N6A 5B9, CanadaUniv Western Ontario, Dept Chem & Biochem Engn, London, ON N6A 5B9, Canada