Metabolomics in atrial fibrillation - A review and meta-analysis of blood, tissue and animal models

被引：3

作者：

Wijdeveld, Leonoor F. J. M. ^{[1
,2
]}

Collinet, Amelie C. T. ^{[1
]}

Huiskes, Fabries G. ^{[1
]}

Brundel, Bianca J. J. M. ^{[1
]}

机构：

[1] Vrije Univ, Dept Physiol, Amsterdam UMC, Amsterdam Cardiovasc Sci Heart Failure & Arrhythmi, NL-1081 HZ Amsterdam, Netherlands

[2] Broad Inst MIT & Harvard, Cardiovasc Dis Initiat, Cambridge, MA 02142 USA

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2024年 / 197卷

关键词：

Atrial fibrillation; Metabolomics; Meta analyses; Atrial tissue; Plasma; Serum; Animal models; CORONARY-ARTERY-DISEASE; TRIMETHYLAMINE-N-OXIDE; HEART-FAILURE; FATTY-ACIDS; PLASMA ACYLCARNITINES; INSULIN-RESISTANCE; STRUCTURAL-CHANGES; SERUM; METABOLISM; RISK;

D O I：

10.1016/j.yjmcc.2024.10.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Atrial fibrillation (AF) is a highly prevalent cardiac arrhythmia associated with severe cardiovascular complications. AF presents a growing global challenge, however, current treatment strategies for AF do not address the underlying pathophysiology. To advance diagnosis and treatment of AF, a deeper understanding of AF root causes is needed. Metabolomics is a fast approach to identify, quantify and analyze metabolites in a given sample, such as human serum or atrial tissue. In the past two decades, metabolomics have enabled research on metabolite biomarkers to predict AF, metabolic features of AF, and testing metabolic mechanisms of AF in animal models. Due to the field's rapid evolution, the methods of AF metabolomics studies have not always been optimal. Metabolomics research has lacked standardization and requires expertise to face methodological challenges. Purpose of the review: We summarize and meta-analyze metabolomics research on AF in human plasma and serum, atrial tissue, and animal models. We present the current progress on metabolic biomarkers candidates, metabolic features of clinical AF, and the translation of metabolomics findings from animal to human. We additionally discuss strengths and weaknesses of the metabolomics method and highlight opportunities for future AF metabolomics research.

引用

页码：108 / 124

页数：17

共 181 条

[31] Disordered gut microbiota promotes atrial fibrillation by aggravated conduction disturbance and unbalanced linoleic acid/SIRT1 signaling [J].

Fang, Chen ;

Zuo, Kun ;

Liu, Zheng ;

Liu, Ye ;

Liu, Lifeng ;

Wang, Yuxing ;

Yin, Xiandong ;

Li, Jing ;

Liu, Xiaoqing ;

Chen, Mulei ;

Yang, Xinchun .

BIOCHEMICAL PHARMACOLOGY, 2023, 213

[32] Interventional Left Atrial Appendage Closure Affects the Metabolism of Acylcarnitines [J].

Fastner, Christian ;

Behnes, Michael ;

Sartorius, Benjamin ;

Wenke, Annika ;

Lang, Siegfried ;

Yuecel, Goekhan ;

Sattler, Katherine ;

Rusnak, Jonas ;

Saleh, Ahmad ;

Barth, Christian ;

Mashayekhi, Kambis ;

Hoffmann, Ursula ;

Borggrefe, Martin ;

Akin, Ibrahim .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (02)

[33] Causal effects of genetically determined metabolites on cancers included lung, breast, ovarian cancer, and glioma: a Mendelian randomization study [J].

Feng, Yi ;

Wang, Runchen ;

Li, Caichen ;

Cai, Xiuyu ;

Huo, Zhenyu ;

Liu, Ziyu ;

Ge, Fan ;

Huang, Chuiguo ;

Lu, Yi ;

Zhong, Ran ;

Li, Jianfu ;

Cheng, Bo ;

Liang, Hengrui ;

Xiong, Shan ;

Mao, Xingyu ;

Chen, Yilin ;

Lan, Ruying ;

Wen, Yaokai ;

Peng, Haoxin ;

Jiang, Yu ;

Su, Zixuan ;

Wu, Xiangrong ;

He, Jianxing ;

Liang, Wenhua .

TRANSLATIONAL LUNG CANCER RESEARCH, 2022, 11 (07) :1302-1314

[34] Association Between Atrial Fibrillation Symptoms, Quality of Life, and Patient Outcomes Results From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) [J].

Freeman, James V. ;

Simon, DaJuanicia N. ;

Go, Alan S. ;

Spertus, John ;

Fonarow, Gregg C. ;

Gersh, Bernard J. ;

Hylek, Elaine M. ;

Kowey, Peter R. ;

Mahaffey, Kenneth W. ;

Thomas, Laine E. ;

Chang, Paul ;

Peterson, Eric D. ;

Piccini, Jonathan P. .

CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES, 2015, 8 (04) :393-402

[35]

García-Pérez MA, 2023, Methods in Psychology, V8, P100120, DOI [10.1016/j.metip.2023.100120, 10.1016/j.metip.2023.100120, DOI 10.1016/J.METIP.2023.100120]

[36] Metabolite profiling of obese individuals before and after a one year weight loss program [J].