Antifungal and anti-biofilm effects of hydrazone derivatives on Candida spp

被引：0

作者：

Popczyk, Pierre ^{[1
]}

Ghinet, Alina ^{[2
,3
,4
]}

Bortolus, Clovis ^{[1
]}

Kamus, Laure ^{[5
,6
]}

Lensink, Marc F. ^{[7
]}

de Ruyck, Jerome ^{[7
]}

Sendid, Boualem ^{[1
]}

Dubar, Faustine ^{[1
]}

机构：

[1] Univ Lille, UGSF Unite Glycobiol Struct & Fonct, INSERM U1285, CHU Lille,UMR CNRS 8576, F-59000 Lille, France

[2] Junia Hlth & Environm Lab Sustainable Chem & Hlth, Lille, France

[3] Univ Lille, Inst Pasteur Lille, Inserm, CHU Lille,UMR 1167,RID AGE Risk Factors & Mol Dete, Lille, France

[4] Alexandru Ioan Cuza Univ, Iasi, Romania

[5] Felix Guyon Hosp Ctr, Dept Med Biol, St Denis, France

[6] Univ La Reunion, UMR Proc Infect Milieu Insulaire Trop PIMIT, CNRS 9192, INSERM U1187,IRD 249, St Denis, France

[7] Univ Lille, UGSF Unite Glycobiol Struct & Fonct, CNRS, UMR 8576, Lille, France

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2024年 / 39卷 / 01期

关键词：

Antifungal; hydrazone; trehalose; Galleria mellonella; biofilm; Candida; TREHALOSE-6-PHOSPHATE PHOSPHATASE; TREHALOSE; DISRUPTION; ACCUMULATION; PATHWAY; DESIGN; BURDEN;

D O I：

10.1080/14756366.2024.2429109

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Worldwide, invasive candidiasis are a burden for the health system due to difficulties to manage patients, to the increasing of the resistance of the current therapeutics and the emergence of naturally resistant species of Candida. In this context, the development of innovative antifungal drugs is urgently needed. During invasive candidiasis, yeast is submitted to many stresses (oxidative, thermic, osmotic) in the human host. In order to resist in this context, yeast develops different strategy, especially the biosynthesis of trehalose. Starting from the 3D structural data of TPS2, an enzyme implicated in trehalose biosynthesis, we identified hydrazone as an interesting scaffold to design new antifungal drugs. Interestingly, our hydrazone derivatives which demonstrate antifungal and anti-biofilm effects on Candida spp., are non-toxic in in vitro and in vivo models (Galleria mellonella).

引用

页数：14

共 47 条

[1] Protective role of trehalose during severe oxidative stress caused by hydrogen peroxide and the adaptive oxidative stress response in Candida albicans [J].