Type 2 diabetes originated from non-alcoholic fatty liver disease

被引：6

作者：

Xiong, Xuelian ^{[1
]}

Li, Xiaoying ^{[1
]}

机构：

[1] Fudan Univ, Zhongshan Hosp, Dept Endocrinol & Metab, Shanghai 200032, Peoples R China

来源：

LIFE METABOLISM | 2023年 / 2卷 / 01期

基金：

中国国家自然科学基金;

关键词：

non-alcoholic fatty liver disease; gluconeogenesis; hepatokine; exercise; HEPATIC STEATOSIS; ASSOCIATION; RECEPTOR; OBESITY;

D O I：

10.1093/lifemeta/load007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Both non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are highly prevalent metabolic liver diseases. Accumulating epidemiological evidence now indicates that NAFLD and T2DM are strongly associated, yet the causative relationship remains to be elucidated. Liver serves as a hub for nutrient and energy metabolism in the body. Here we demonstrated the pathogenesis linking NAFLD to T2DM through a series of studies and the attenuation of T2DM progression after NALFD improvement in cohort study. We proposed the urgent necessity of NAFLD management and NAFLD drug development, which might be novel therapeutic avenues for T2DM.

引用

页数：3

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