Structures of new cytotoxic bicyclic hexapeptides with a phenylpropanoid unit from Rubia cordifolia

被引：1

作者：

Fukaya, Haruhiko ^{[1
]}

Kitamura, Rie ^{[1
]}

Hasuda, Tomoyo ^{[1
]}

Takeya, Koichi ^{[1
]}

Aoyagi, Yutaka ^{[2
]}

Nakane, Takahisa ^{[3
]}

Hitotsuyanagi, Yukio ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, 1432-1 Horinouchi, Hachioji, Tokyo 1920392, Japan

[2] Kinjo Gakuin Univ, Coll Pharm, 2-1723 Omori,Moriyama Ku, Nagoya, Aichi 4638521, Japan

[3] Showa Pharmaceut Univ, 3-3165 Higashi Tamagawagakuen, Machida, Tokyo 1948543, Japan

来源：

PHYTOCHEMISTRY LETTERS | 2025年 / 65卷

关键词：

Deoxybouvardin; Phenylpropanoid; Rubia cordifolia; Cytotoxicity; ANTITUMOR CYCLIC HEXAPEPTIDES; PROTEIN-SYNTHESIS; BOUVARDIN; CYCLOPEPTIDES;

D O I：

10.1016/j.phytol.2024.12.004

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four bicyclic hexapeptides RA-XXIX-RA-XXXII, which have a phenylpropanoid unit attached to the hydroxy group of the Tyr-6 residue of deoxybouvardin, were isolated from the roots of Rubia cordifolia L. Their structures were established on the basis of spectroscopic data, the X-ray crystallography of 4-O-methyl-RA-XXIX tribromide, and the chemical conversion of RA-XXIX and RA-XXX into RA-XXXII and RA-XXXI, respectively. RA-XXIX-RAXXXII exhibited 420-960 times and 53-330 times lower cytotoxicity than RA-VII toward the HL-60 and HCT-116 cell lines, respectively.

引用

页码：82 / 88

页数：7

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