Analysis of Risk Factors, Treatment Patterns, and Survival Outcomes After Emergency Presentation With Colorectal Cancer: A Prospective Multicenter Cohort Study in Nigeria

被引：0

作者：

Aderibigbe, Adeniyi S. ^{[1
]}

Dare, Anna J. ^{[2
,3
]}

Kalvin, Hannah L. ^{[4
]}

Olasehinde, Olalekan ^{[5
]}

Wuraola, Funmilola ^{[5
]}

Adisa, Adewale ^{[5
]}

Omisore, Adeleye Dorcas ^{[6
]}

Komolafe, Akinwumi O. ^{[7
]}

Omoyiola, Oluwatosin Zainab ^{[7
]}

Okereke, Chukwuma Eze ^{[1
]}

Katung, Aba ^{[1
]}

Egberoungbe, Adedeji ^{[8
]}

Ariyibi, Olufemi ^{[9
]}

Olatoke, Samuel Adegboyega ^{[10
]}

Adeyeye, Ademola Adetoyese ^{[10
]}

Agodirin, Sulaiman Olayide ^{[10
]}

Bojuwoye, Matthew Olumuyiwa ^{[11
]}

Fayenuwo, James Oluwaleke ^{[12
]}

Ademakinwa, Oluwabusayomi Roseline ^{[12
]}

Osinowo, Dapo ^{[13
]}

Lawal, Abdul-Razak ^{[13
]}

Abdulkareem, Fatimah B. ^{[13
]}

Goldman, Debra ^{[4
]}

Knapp, Gregory ^{[14
]}

Murthy, Shilpa ^{[15
]}

Kahn, Rivka ^{[16
]}

Gonen, Mithat ^{[1
]}

Kingham, T. Peter ^{[16
,17
]}

Alatise, Olusegun I. ^{[5
,12
]}

机构：

[1] Fed Med Ctr, Dept Surg, Owo, Ondo State, Nigeria

[2] St Michaels Hosp, Dept Surg, Toronto, ON, Canada

[3] Univ Toronto, Toronto, ON, Canada

[4] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY USA

[5] Obafemi Awolowo Univ, Coll Hlth Sci, Dept Surg, Ife, Osun State, Nigeria

[6] Obafemi Awolowo Univ, Coll Hlth Sci, Dept Radiol, Ife, Osun State, Nigeria

[7] Obafemi Awolowo Univ, Coll Hlth Sci, Dept Morbid Anat, Ife, Osun State, Nigeria

[8] Fed Med Ctr, Dept Radiol, Owo, Ondo State, Nigeria

[9] Fed Med Ctr, Dept Pathol, Owo, Ondo State, Nigeria

[10] Univ Ilorin, Teaching Hosp, Teaching Hosp, Ilorin, Kwara State, Nigeria

[11] Univ Ilorin, Dept Med, Teaching Hosp, Ilorin, Kwara State, Nigeria

[12] African Res Grp Oncol, Ife, Osun State, Nigeria

[13] Univ Lagos, Lagos Univ Teaching Hosp, Dept Radiol, Lagos, Nigeria

[14] Dalhousie Univ, Dept Surg, Div Gen Surg, Halifax, NS, Canada

[15] Yale Sch Med, Dept Surg, New Haven, CT USA

[16] Mem Sloan Kettering Canc Ctr, Global Canc Dispar Initiat, New York, NY 10065 USA

[17] Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10065 USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2025年 / 131卷 / 02期

基金：

美国国家卫生研究院;

关键词：

cancer survival; colorectal cancer; emergency presentation; low- and middle-income countries (LMICs); Nigeria; West Africa; DIAGNOSIS; IMPACT; PERFORATION; OBSTRUCTION; ADMISSION; SURGERY; TRENDS;

D O I：

10.1002/jso.27878

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background and ObjectivesProspective data on presentation and outcomes of colorectal cancer (CRC) in Nigeria are limited; however, emergency presentation with advanced disease is thought common. MethodsConsecutive CRC patients presenting at six sites over 6 years were included. Risk factors for emergency presentation were evaluated using logistic regression methods. Overall survival (OS) was compared between emergent and elective patients using Kaplan-Meier methods and the log-rank test. ResultsOf 535 patients, 30.7% presented emergently. Median age was 56 years, 55% were men, and 5.0% reported a cancer family history. Emergency patients had more proximal cancers (42.1% vs. 24.0%), Stage IV disease (61.6% vs. 40.2%; p < 0.001), lower household income ((sic)35 000/month vs. (sic)50 000/month), lower education levels (p = 0.008) and accessed care with nonmotorized transport (50.6% vs. 37.2%; p = 0.005). Median OS was shorter in the emergency group (6.4 vs. 17.4 months; p < 0.001). Across clinical stages, emergency presentation was associated with worse OS (Stage IV median OS 4.8 vs. 9.4 months; p = 0.002). Surgery improved survival in both groups, although emergency patients had higher 30-day postoperative mortality (23.2% vs. 9.1%; p < 0.001). ConclusionsEmergent Nigerian CRC patients have worse OS than elective patients. Cancer control efforts should focus on faster cancer detection, early presentation, diagnosis, and treatment.

引用

页码：170 / 182

页数：13

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