Demographic and regional trends in systemic and cardiovascular amyloidosis-related mortality among older adults in the United States from 1999 to 2020

被引:0
作者
Dhaliwal, Jasninder Singh [1 ]
Hussain, Fatima [2 ]
Ahmed, Hamza [2 ]
Khan, Abeer T. M. A. [3 ]
Khan, Abdullah Aslam [3 ]
Memon, Maha Asghar [4 ]
Arshad, Maha [4 ]
Mehdi, Sayed Maisum [2 ]
Hussain, Anum Touseef [5 ]
Rind, Ayesha Ali [4 ]
Munir, Syeda Umbreen [6 ]
Ali, Bilal [7 ]
Nadeem, Kashaf [8 ]
Rashid, Ahmed Mustafa [8 ]
机构
[1] Univ Calif Riverside, Internal Med Resident, Riverside, CA USA
[2] Dow Univ Hlth Sci, Dow Int Med Coll, Dept Med, POB 74200, Karachi, Pakistan
[3] Rawal Inst Hlth Sci, Dept Med, Islamabad, Pakistan
[4] Ziauddin Univ, Dept Med, Karachi, Pakistan
[5] CMH Lahore Med & Dent Coll, Dept Med, Lahore, Pakistan
[6] Karachi Med & Dent Coll, Dept Med, Karachi, Pakistan
[7] Dow Univ Hlth Sci, Dept Med, Karachi, Pakistan
[8] Jinnah Sindh Med Univ, Dept Med, Karachi, Pakistan
关键词
Amyloidosis; Cardiomyopathies; Mortality; Older adults; Trends;
D O I
10.1007/s11739-025-03893-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Despite therapy advancements, amyloidosis mortality rates for older adults (aged >= 65) are rising. This study analyzes trends in amyloidosis-related mortality among older adults in the U.S. We conducted a cross-sectional analysis of death certificates from the CDC WONDER database for amyloidosis-related deaths from 1999 to 2020. Age-adjusted mortality rates (AAMRs) per 100,000 persons and annual percent change (APC) were calculated by age, race/ethnicity, urban-rural classification, and region. From 1999 to 2020, AAMR for amyloidosis in older adults (aged >= 65) in the U.S. increased from 2.7 to 5.6. Men consistently had higher AAMRs than women (men: 3.7 vs. women: 2.2 in 1999; men: 8.5 vs. women: 3.5 in 2020). In 2020, Non-Hispanic Blacks had the highest AAMR at 11.8, with an APC of 19.8 (95% CI 10.5-25.5). Regional differences were notable, with AAMRs highest in the Northeast (6.9) and lowest in the South (4.2). Large metropolitan areas had a higher AAMR (6.3) than non-metropolitan areas (4.6). Cardiac amyloidosis accounted for 68.8% of deaths, with AAMR rising from 1.7 to 4.2. There has been a significant increase in AAMRs for amyloidosis in the U.S. from 1999 to 2020, particularly among males, Non-Hispanic Blacks, and those in large metropolitan and Northeast areas. These findings stress the need for enhanced prevention and treatment strategies for older adults.
引用
收藏
页码:1003 / 1012
页数:10
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