Demographic and regional trends in systemic and cardiovascular amyloidosis-related mortality among older adults in the United States from 1999 to 2020

被引：0

作者：

Dhaliwal, Jasninder Singh ^{[1
]}

Hussain, Fatima ^{[2
]}

Ahmed, Hamza ^{[2
]}

Khan, Abeer T. M. A. ^{[3
]}

Khan, Abdullah Aslam ^{[3
]}

Memon, Maha Asghar ^{[4
]}

Arshad, Maha ^{[4
]}

Mehdi, Sayed Maisum ^{[2
]}

Hussain, Anum Touseef ^{[5
]}

Rind, Ayesha Ali ^{[4
]}

Munir, Syeda Umbreen ^{[6
]}

Ali, Bilal ^{[7
]}

Nadeem, Kashaf ^{[8
]}

Rashid, Ahmed Mustafa ^{[8
]}

机构：

[1] Univ Calif Riverside, Internal Med Resident, Riverside, CA USA

[2] Dow Univ Hlth Sci, Dow Int Med Coll, Dept Med, POB 74200, Karachi, Pakistan

[3] Rawal Inst Hlth Sci, Dept Med, Islamabad, Pakistan

[4] Ziauddin Univ, Dept Med, Karachi, Pakistan

[5] CMH Lahore Med & Dent Coll, Dept Med, Lahore, Pakistan

[6] Karachi Med & Dent Coll, Dept Med, Karachi, Pakistan

[7] Dow Univ Hlth Sci, Dept Med, Karachi, Pakistan

[8] Jinnah Sindh Med Univ, Dept Med, Karachi, Pakistan

来源：

INTERNAL AND EMERGENCY MEDICINE | 2025年

关键词：

Amyloidosis; Cardiomyopathies; Mortality; Older adults; Trends;

D O I：

10.1007/s11739-025-03893-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Despite therapy advancements, amyloidosis mortality rates for older adults (aged >= 65) are rising. This study analyzes trends in amyloidosis-related mortality among older adults in the U.S. We conducted a cross-sectional analysis of death certificates from the CDC WONDER database for amyloidosis-related deaths from 1999 to 2020. Age-adjusted mortality rates (AAMRs) per 100,000 persons and annual percent change (APC) were calculated by age, race/ethnicity, urban-rural classification, and region. From 1999 to 2020, AAMR for amyloidosis in older adults (aged >= 65) in the U.S. increased from 2.7 to 5.6. Men consistently had higher AAMRs than women (men: 3.7 vs. women: 2.2 in 1999; men: 8.5 vs. women: 3.5 in 2020). In 2020, Non-Hispanic Blacks had the highest AAMR at 11.8, with an APC of 19.8 (95% CI 10.5-25.5). Regional differences were notable, with AAMRs highest in the Northeast (6.9) and lowest in the South (4.2). Large metropolitan areas had a higher AAMR (6.3) than non-metropolitan areas (4.6). Cardiac amyloidosis accounted for 68.8% of deaths, with AAMR rising from 1.7 to 4.2. There has been a significant increase in AAMRs for amyloidosis in the U.S. from 1999 to 2020, particularly among males, Non-Hispanic Blacks, and those in large metropolitan and Northeast areas. These findings stress the need for enhanced prevention and treatment strategies for older adults.

引用

页码：1003 / 1012

页数：10