Potential impact of severe hydronephrosis secondary to ureteropelvic junction obstruction on pediatric blood pressure

被引：0
|
作者：
Tian, Qingqing [1 ]
Zhang, Chu [1 ]
Zhao, Xiang [1 ]
Yu, Kechi [1 ]
Fang, Erhu [1 ]
Zhou, Xuefeng [1 ]
Niu, Yonghua [1 ]
Li, Ning [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pediat Surg, Wuhan, Peoples R China
来源：
JOURNAL OF PEDIATRIC UROLOGY | 2025年 / 21卷 / 01期
关键词：
Hydronephrosis; Ureteropelvic junction obstruction; Blood pressure; Children; Renin; Aldosterone; SALT-SENSITIVE HYPERTENSION;
D O I：
10.1016/j.jpurol.2024.10.014
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
This study enrolled 114 children with severe hydronephrosis secondary to UPJO and 153 without nephritic or cardiovascular conditions between September 2021 and June 2023. As the control group aged, SBP and DBP increased, whereas ARC and AC decreased. Overall, hydronephrosis group had higher SBP, DBP, ARC, and AC than the controls group. These differences differed between the age groups. After pyeloplasty, the postoperative BP of hydronephrosis group approximated that of the control group. Postoperative ARC levels were higher than those in the control group but were much lower than the preoperative levels. AC did not decrease significantly after surgery. The change in DBP in children with hydronephrosis before and after pyeloplasty showed a positive correlation with the change in AC. renin-angiotensin-aldosterone system (RAAS) were examined. Results This study enrolled 114 children with severe hydronephrosis secondary to UPJO and 153 without nephritic or cardiovascular conditions between September 2021 and June 2023. As the control group aged, SBP and DBP increased, whereas ARC and AC decreased. Overall, hydronephrosis group had higher SBP, DBP, ARC, and AC than the controls group. These differences differed between the age groups. After pyeloplasty, the postoperative BP of hydronephrosis group approximated that of the control group. Postoperative ARC levels were higher than those in the control group but were much lower than the preoperative levels. AC did not decrease significantly after surgery. The change in DBP in children with hydronephrosis before and after pyeloplasty showed a positive correlation with the change in AC. Conclusions Pediatric patients with severe hydronephrosis, a condition secondary to UPJO, displayed elevated BP, ARC, and AC. Following pyeloplasty, these patients noted a reduction in BP. The correlation between elevated blood pressure and the RAAS necessitates further comprehensive investigation.
引用
收藏
页码：108 / 114
页数：7
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